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@ARTICLE{Mariano:1008645,
author = {Mariano, Anna and Fasolino, Ines and Dinger, Nikita Bhupesh
and Latte Bovio, Claudia and Bonadies, Irene and Pezzella,
Alessandro and Ambrosio, Luigi and Raucci, Maria Grazia and
Santoro, Francesca},
title = {{E}umelanin‐{C}oated {A}ligned {PLA} {E}lectrospun
{M}icrofibers to {G}uide {SH}‐{SY}5{YC}ells {S}preading,
{A}lignment, {A}nd {M}aturation},
journal = {Advanced materials interfaces},
volume = {10},
number = {9},
issn = {2196-7350},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {FZJ-2023-02446},
pages = {2202022 -},
year = {2023},
abstract = {During the development of the nervous system, neurons sense
and respond to topographical and biochemical cues found in
the brain's native environment. Such niche-specific cues are
pivotal for neural tissue formation and development and have
been now widely exploited in neural tissue engineering to
develop biologically-inspired scaffolds able to trigger a
desired neuronal behavior. In particular, anisotropic
aligned fibers, recapitulating the design of extending
axonal tracts or aligned fibers found in the extracellular
environment, have emerged as ideal candidates to guide cell
alignment and elongation along the substrate main axis as
well as promote neuronal differentiation. Among natural
polymers used for coatings, melanins, including eumelanin,
have been shown to possess antioxidant, anti-inflammatory,
immunomodulatory, and photo-protective properties. Here,
aligned poly(lactic acid) (PLA) fibers are fabricated via
electrospinning and then coated with eumelanin via spin
coating. Eumelanin-coated aligned PLA fibers are highly
biocompatible and greatly influenced the adhesion,
morphology, and spreading of SH-SY5Y neuroblastoma cells.
Furthermore, the eumelanin coating is crucial in promoting
cell alignment at the cell-material interface and SH-SY5Y
cell maturation towards a more mature neuronal phenotype.},
cin = {IBI-3},
ddc = {600},
cid = {I:(DE-Juel1)IBI-3-20200312},
pnm = {5244 - Information Processing in Neuronal Networks
(POF4-524)},
pid = {G:(DE-HGF)POF4-5244},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000937599900001},
doi = {10.1002/admi.202202022},
url = {https://juser.fz-juelich.de/record/1008645},
}