%0 Journal Article
%A Hänisch, Benjamin
%A Hansen, Justine Y
%A Bernhardt, Boris C
%A Eickhoff, Simon B
%A Dukart, Juergen
%A Misic, Bratislav
%A Valk, Sofie Louise
%T Cerebral chemoarchitecture shares organizational traits with brain structure and function
%J eLife
%V 12
%@ 2050-084X
%C Cambridge
%I eLife Sciences Publications
%M FZJ-2023-02934
%P e83843
%D 2023
%X Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure–function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors. Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity – a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient. In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis. Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis. Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37440423
%U <Go to ISI:>//WOS:001071084300001
%R 10.7554/eLife.83843
%U https://juser.fz-juelich.de/record/1009681