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001009681 1001_ $$0P:(DE-HGF)0$$aHänisch, Benjamin$$b0
001009681 245__ $$aCerebral chemoarchitecture shares organizational traits with brain structure and function
001009681 260__ $$aCambridge$$beLife Sciences Publications$$c2023
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001009681 520__ $$aChemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure–function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors. Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity – a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient. In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis. Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis. Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility.
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001009681 7001_ $$0P:(DE-HGF)0$$aHansen, Justine Y$$b1
001009681 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C$$b2
001009681 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B$$b3
001009681 7001_ $$0P:(DE-Juel1)177727$$aDukart, Juergen$$b4
001009681 7001_ $$0P:(DE-HGF)0$$aMisic, Bratislav$$b5
001009681 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie Louise$$b6$$eCorresponding author
001009681 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.83843$$gVol. 12, p. e83843$$pe83843$$teLife$$v12$$x2050-084X$$y2023
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