TY  - JOUR
AU  - Hänisch, Benjamin
AU  - Hansen, Justine Y
AU  - Bernhardt, Boris C
AU  - Eickhoff, Simon B
AU  - Dukart, Juergen
AU  - Misic, Bratislav
AU  - Valk, Sofie Louise
TI  - Cerebral chemoarchitecture shares organizational traits with brain structure and function
JO  - eLife
VL  - 12
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - FZJ-2023-02934
SP  - e83843
PY  - 2023
AB  - Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure–function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors. Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity – a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient. In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis. Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis. Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility.
LB  - PUB:(DE-HGF)16
C6  - 37440423
UR  - <Go to ISI:>//WOS:001071084300001
DO  - DOI:10.7554/eLife.83843
UR  - https://juser.fz-juelich.de/record/1009681
ER  -