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@ARTICLE{Hnisch:1009681,
      author       = {Hänisch, Benjamin and Hansen, Justine Y and Bernhardt,
                      Boris C and Eickhoff, Simon B and Dukart, Juergen and Misic,
                      Bratislav and Valk, Sofie Louise},
      title        = {{C}erebral chemoarchitecture shares organizational traits
                      with brain structure and function},
      journal      = {eLife},
      volume       = {12},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2023-02934},
      pages        = {e83843},
      year         = {2023},
      abstract     = {Chemoarchitecture, the heterogeneous distribution of
                      neurotransmitter transporter and receptor molecules, is a
                      relevant component of structure–function relationships in
                      the human brain. Here, we studied the organization of the
                      receptome, a measure of interareal chemoarchitectural
                      similarity, derived from positron-emission tomography
                      imaging studies of 19 different neurotransmitter
                      transporters and receptors. Nonlinear dimensionality
                      reduction revealed three main spatial gradients of cortical
                      chemoarchitectural similarity – a centro-temporal
                      gradient, an occipito-frontal gradient, and a
                      temporo-occipital gradient. In subcortical nuclei,
                      chemoarchitectural similarity distinguished functional
                      communities and delineated a striato-thalamic axis. Overall,
                      the cortical receptome shared key organizational traits with
                      functional and structural brain anatomy, with node-level
                      correspondence to functional, microstructural, and diffusion
                      MRI-based measures decreasing along a primary-to-transmodal
                      axis. Relative to primary and paralimbic regions, unimodal
                      and heteromodal regions showed higher receptomic
                      diversification, possibly supporting functional
                      flexibility.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37440423},
      UT           = {WOS:001071084300001},
      doi          = {10.7554/eLife.83843},
      url          = {https://juser.fz-juelich.de/record/1009681},
}