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@ARTICLE{Kroll:1009716,
      author       = {Kroll, Tina and Grözinger, Michael and Matusch, Andreas
                      and Elmenhorst, David and Novakovic, Ana and Schneider,
                      Frank and Bauer, Andreas},
      title        = {{E}ffects of electroconvulsive therapy on cerebral {A}1
                      adenosine receptor availability: a {PET} study in patients
                      suffering from treatment-resistant major depressive
                      disorder},
      journal      = {Frontiers in psychiatry},
      volume       = {14},
      issn         = {1664-0640},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2023-02948},
      pages        = {1228438},
      year         = {2023},
      abstract     = {Sleep deprivation and electroconvulsive therapy (ECT)
                      effectively ameliorate symptoms in major depressive disorder
                      (MDD). In rodents, both are associated with an enhancement
                      of cerebral adenosine levels, which in turn likely influence
                      adenosinergic receptor expression. The aim of the current
                      study was to investigate cerebral A1 adenosine receptor
                      (A1AR) availability in patients with MDD as a potential
                      mediating factor of antidepressant effects of ECT using
                      [18F]CPFPX and positron emission tomography (PET).Regional
                      A1AR availability was determined before and after a series
                      of ECT applications (mean number ± SD 10.4 ± 1.2) in 14
                      subjects (4 males, mean age 49.5 ± 11.8 years). Clinical
                      outcome, measured by neuropsychological testing, and ECT
                      parameters were correlated with changes in A1AR
                      availability.ECT had a strong antidepressive effect
                      (p < 0.01) while on average cerebral A1AR availability
                      remained unaltered between pre-and post-ECT conditions
                      (F = 0.65, p = 0.42, mean difference ± SD $3.93\%$
                      ± $22.7\%).$ There was no correlation between changes in
                      clinical outcome parameters and regional A1AR availability,
                      although individual patients showed striking bidirectional
                      alterations of up to $30–40\%$ in A1AR availability after
                      ECT. Solely, for the mean seizure quality index of the
                      applied ECTs a significant association with changes in A1AR
                      availability was found (rs = −0.6, p = 0.02).In
                      the present study, therapeutically effective ECT treatment
                      did not result in coherent changes of A1AR availability
                      after a series of ECT treatments. These findings do not
                      exclude a potential role for cerebral A1ARs in ECT, but
                      shift attention to rather short-termed and adaptive
                      mechanisms during ECT-related convulsive effects.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5253 -
                      Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37520217},
      UT           = {WOS:001035260100001},
      doi          = {10.3389/fpsyt.2023.1228438},
      url          = {https://juser.fz-juelich.de/record/1009716},
}