TY  - EJOUR
AU  - Herrera-Rivero, Marisol
AU  - Gutiérrez-Fragoso, Karina
AU  - Thalamuthu, Anbupalam
AU  - Amare, Azmeraw T.
AU  - Adli, Mazda
AU  - Akiyama, Kazufumi
AU  - Akula, Nirmala
AU  - Ardau, Raffaella
AU  - Arias, Bárbara
AU  - Aubry, Jean-Michel
AU  - Backlund, Lena
AU  - Bellivier, Frank
AU  - Benabarre, Antonio
AU  - Bengesser, Susanne
AU  - Abesh, Bhattacharjee
AU  - Biernacka, Joanna
AU  - Birner, Armin
AU  - Cearns, Micah
AU  - Cervantes, Pablo
AU  - Chen, Hsi-Chung
AU  - Chillotti, Caterina
AU  - Cichon, Sven
AU  - Clark, Scott
AU  - Colom, Francesc
AU  - Cruceanu, Cristiana
AU  - Czerski, Piotr
AU  - Dalkner, Nina
AU  - Degenhardt, Franziska
AU  - Zompo, Maria Del
AU  - DePaulo, J. Raymond
AU  - Etain, Bruno
AU  - Falkai, Peter
AU  - Ferensztajn-Rochowiak, Ewa
AU  - Forstner, Andreas J.
AU  - Frank, Josef
AU  - Frisen, Louise
AU  - Frye, Mark
AU  - Fullerton, Janice
AU  - Gallo, Carla
AU  - Gard, Sebastien
AU  - Garnham, Julie
AU  - Goes, Fernando
AU  - Grigoroiu-Serbanescu, Maria
AU  - Grof, Paul
AU  - Hashimoto, Ryota
AU  - Hasler, Roland
AU  - Hauser, Joanna
AU  - Heilbronner, Urs
AU  - Herms, Stefan
AU  - Hoffmann, Per
AU  - Hou, Liping
AU  - Hsu, YiHsiang
AU  - Jamain, Stéphane
AU  - Jiménez, Esther
AU  - Kahn, Jean-Pierre
AU  - Kassem, Layla
AU  - Kato, Tadafumi
AU  - Kelsoe, John
AU  - Kittel-Schneider, Sarah
AU  - kuo, Po-Hsiu
AU  - Kurtz, Joachim
AU  - Kusumi, Ichiro
AU  - König, Barbara
AU  - Laje, Gonzalo
AU  - Landén, Mikael
AU  - Lavebratt, Catharina
AU  - Leboyer, Marion
AU  - Leckband, Susan
AU  - Maj, Mario
AU  - Manchia, Mirko
AU  - Marie-Claire, Cynthia
AU  - Martinsson, Lina
AU  - McCarthy, Michael
AU  - McElroy, Susan L.
AU  - Millischer, Vincent
AU  - Mitjans, Marina
AU  - Mondimore, Francis
AU  - Monteleone, Palmiero
AU  - Nievergelt, Caroline
AU  - Novak, Tomas
AU  - Nöthen, Markus
AU  - odonovan, claire
AU  - Ozaki, Norio
AU  - Papiol, Sergi
AU  - Pfennig, Andrea
AU  - Pisanu, Claudia
AU  - Potash, James
AU  - Reif, Andreas
AU  - Reininghaus, Eva
AU  - Richard-Lepouriel, Hélène
AU  - Roberts, Gloria
AU  - Rouleau, Guy
AU  - Rybakowski, Janusz K.
AU  - Schalling, Martin
AU  - Schofield, Peter
AU  - Schubert, Klaus Oliver
AU  - Schulte, Eva
AU  - SCHWEIZER, BARBARA
AU  - Severino, Giovanni
AU  - Shekhtman, Tatyana
AU  - Shilling, Paul
AU  - Shimoda, Kazutaka
AU  - Simhandl, Christian
AU  - slaney, claire
AU  - Squassina, Alessio
AU  - Stamm, Thomas
AU  - Stopkova, Pavla
AU  - Streit, Fabian
AU  - Ayele, Fasil
AU  - Tortorella, Alfonso
AU  - Turecki, Gustavo
AU  - Veeh, Julia
AU  - Vieta, Eduard
AU  - Viswanath, Biju
AU  - Witt, Stephanie
AU  - Zandi, Peter
AU  - Alda, Martin
AU  - Bauer, Michael
AU  - McMahon, Francis
AU  - Mitchell, Philip
AU  - Rietschel, Marcella
AU  - Schulze, Thomas
AU  - Baune, Bernhard
TI  - Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder
M1  - FZJ-2023-02975
PY  - 2023
AB  - The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi + Gen, N = 2,374). Second, we calculated here previously published polygenic scores (PGSs) for immune-related traits and evaluated their associations with Li response and clinical features. We found several genes associated with Li response at p < 1x10 - 4 values, including HAS3 , CNTNAP5 and NFIB . Network and functional enrichment analyses uncovered an overrepresentation of pathways involved in cell adhesion and intercellular communication, which appear to converge on the well-known Li-induced inhibition of GSK-3β. We also found various genes associated with BP's age-at-onset, number of mood episodes, and presence of psychosis, substance abuse and/or suicidal ideation at the exploratory threshold. These included RTN4 , XKR4 , NRXN1 , NRG1/3 and GRK5 . Additionally, PGS analyses suggested serum FAS, ECP, TRANCE and cytokine ligands, amongst others, might represent potential circulating biomarkers of Li response and clinical presentation. Taken together, our results support the notion of a relatively weak association between immunity and clinically relevant features of BP at the genetic level.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.21203/rs.3.rs-3068352/v1
UR  - https://juser.fz-juelich.de/record/1010147
ER  -