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@ARTICLE{HerreraRivero:1010147,
      author       = {Herrera-Rivero, Marisol and Gutiérrez-Fragoso, Karina and
                      Thalamuthu, Anbupalam and Amare, Azmeraw T. and Adli, Mazda
                      and Akiyama, Kazufumi and Akula, Nirmala and Ardau,
                      Raffaella and Arias, Bárbara and Aubry, Jean-Michel and
                      Backlund, Lena and Bellivier, Frank and Benabarre, Antonio
                      and Bengesser, Susanne and Abesh, Bhattacharjee and
                      Biernacka, Joanna and Birner, Armin and Cearns, Micah and
                      Cervantes, Pablo and Chen, Hsi-Chung and Chillotti, Caterina
                      and Cichon, Sven and Clark, Scott and Colom, Francesc and
                      Cruceanu, Cristiana and Czerski, Piotr and Dalkner, Nina and
                      Degenhardt, Franziska and Zompo, Maria Del and DePaulo, J.
                      Raymond and Etain, Bruno and Falkai, Peter and
                      Ferensztajn-Rochowiak, Ewa and Forstner, Andreas J. and
                      Frank, Josef and Frisen, Louise and Frye, Mark and
                      Fullerton, Janice and Gallo, Carla and Gard, Sebastien and
                      Garnham, Julie and Goes, Fernando and Grigoroiu-Serbanescu,
                      Maria and Grof, Paul and Hashimoto, Ryota and Hasler, Roland
                      and Hauser, Joanna and Heilbronner, Urs and Herms, Stefan
                      and Hoffmann, Per and Hou, Liping and Hsu, YiHsiang and
                      Jamain, Stéphane and Jiménez, Esther and Kahn, Jean-Pierre
                      and Kassem, Layla and Kato, Tadafumi and Kelsoe, John and
                      Kittel-Schneider, Sarah and kuo, Po-Hsiu and Kurtz, Joachim
                      and Kusumi, Ichiro and König, Barbara and Laje, Gonzalo and
                      Landén, Mikael and Lavebratt, Catharina and Leboyer, Marion
                      and Leckband, Susan and Maj, Mario and Manchia, Mirko and
                      Marie-Claire, Cynthia and Martinsson, Lina and McCarthy,
                      Michael and McElroy, Susan L. and Millischer, Vincent and
                      Mitjans, Marina and Mondimore, Francis and Monteleone,
                      Palmiero and Nievergelt, Caroline and Novak, Tomas and
                      Nöthen, Markus and odonovan, claire and Ozaki, Norio and
                      Papiol, Sergi and Pfennig, Andrea and Pisanu, Claudia and
                      Potash, James and Reif, Andreas and Reininghaus, Eva and
                      Richard-Lepouriel, Hélène and Roberts, Gloria and Rouleau,
                      Guy and Rybakowski, Janusz K. and Schalling, Martin and
                      Schofield, Peter and Schubert, Klaus Oliver and Schulte, Eva
                      and SCHWEIZER, BARBARA and Severino, Giovanni and Shekhtman,
                      Tatyana and Shilling, Paul and Shimoda, Kazutaka and
                      Simhandl, Christian and slaney, claire and Squassina,
                      Alessio and Stamm, Thomas and Stopkova, Pavla and Streit,
                      Fabian and Ayele, Fasil and Tortorella, Alfonso and Turecki,
                      Gustavo and Veeh, Julia and Vieta, Eduard and Viswanath,
                      Biju and Witt, Stephanie and Zandi, Peter and Alda, Martin
                      and Bauer, Michael and McMahon, Francis and Mitchell, Philip
                      and Rietschel, Marcella and Schulze, Thomas and Baune,
                      Bernhard},
      title        = {{I}mmunogenetics of lithium response and psychiatric
                      phenotypes in patients with bipolar disorder},
      reportid     = {FZJ-2023-02975},
      year         = {2023},
      abstract     = {The link between bipolar disorder (BP) and immune
                      dysfunction remains controversial. While epidemiological
                      studies have long suggested an association, recent research
                      has found only limited evidence of such a relationship. To
                      clarify this, we investigated the contributions of
                      immune-relevant genetic factors to the response to lithium
                      (Li) treatment and the clinical presentation of BP. First,
                      we assessed the association of a large collection of
                      immune-related genes (4,925) with Li response, defined by
                      the Retrospective Assessment of the Lithium Response
                      Phenotype Scale (Alda scale), and clinical characteristics
                      in patients with BP from the International Consortium on
                      Lithium Genetics (ConLi + Gen, N = 2,374). Second, we
                      calculated here previously published polygenic scores (PGSs)
                      for immune-related traits and evaluated their associations
                      with Li response and clinical features. We found several
                      genes associated with Li response at p < 1x10 - 4 values,
                      including HAS3 , CNTNAP5 and NFIB . Network and functional
                      enrichment analyses uncovered an overrepresentation of
                      pathways involved in cell adhesion and intercellular
                      communication, which appear to converge on the well-known
                      Li-induced inhibition of GSK-3β. We also found various
                      genes associated with BP's age-at-onset, number of mood
                      episodes, and presence of psychosis, substance abuse and/or
                      suicidal ideation at the exploratory threshold. These
                      included RTN4 , XKR4 , NRXN1 , NRG1/3 and GRK5 .
                      Additionally, PGS analyses suggested serum FAS, ECP, TRANCE
                      and cytokine ligands, amongst others, might represent
                      potential circulating biomarkers of Li response and clinical
                      presentation. Taken together, our results support the notion
                      of a relatively weak association between immunity and
                      clinically relevant features of BP at the genetic level.},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.21203/rs.3.rs-3068352/v1},
      url          = {https://juser.fz-juelich.de/record/1010147},
}