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@ARTICLE{Burghaus:1010192,
      author       = {Burghaus, Lothar and Madlener, Marie and Kohle, Felix and
                      Bruno, Emanuel F. and Limmroth, Volker and Fink, Gereon
                      Rudolf and Malter, Michael P.},
      title        = {{P}rehospital {L}evetiracetam {U}se in {A}dults {W}ith
                      {S}tatus {E}pilepticus: {R}esults of a {M}ulticenter
                      {R}egistry},
      journal      = {Journal of clinical neurology},
      volume       = {19},
      number       = {4},
      issn         = {1738-6586},
      address      = {Seoul},
      publisher    = {[Verlag nicht ermittelbar]},
      reportid     = {FZJ-2023-03003},
      pages        = {365 -},
      year         = {2023},
      abstract     = {Background and PurposeStatus epilepticus (SE) is a
                      neurological emergency due to prolonged seizure activity or
                      multiple seizures without full recovery in between them.
                      Prehospital SE management is crucial since its duration is
                      correlated with higher morbidity and mortality rates. We
                      examined the impact of different therapeutic strategies in
                      the prehospital setting with a focus on
                      levetiracetam.MethodsWe initiated the Project for SE in
                      Cologne, a scientific association of all neurological
                      departments of Cologne, the fourth-largest city in Germany
                      with around 1,000,000 inhabitants. All patients with an SE
                      diagnosis were evaluated over 2 years (from March 2019 to
                      February 2021) to determine whether prehospital
                      levetiracetam use had a significant effect on SE
                      parameters.ResultsWe identified 145 patients who received
                      initial drug therapy in the prehospital setting by
                      professional medical staff. Various benzodiazepine (BZD)
                      derivatives were used as first-line treatments, which were
                      mostly used in line with the recommended guidelines.
                      Levetiracetam was regularly used (n=42) and mostly in
                      combination with BZDs, but no significant additional effect
                      was observed for intravenous levetiracetam. However, it
                      appeared that the administered doses tended to be
                      low.ConclusionsLevetiracetam can be applied to adults with
                      SE in prehospital settings with little effort. Nevertheless,
                      the prehospital treatment regimen described here for the
                      first time did not significantly improve the preclinical
                      cessation rate of SE. Future therapy concepts should be
                      based on this, and the effects of higher doses should in
                      particular be reexamined. Keywords:neurological emergency;
                      prehospital setting; anticonvulsant therapy;
                      benzodiazepines; levetiracetam},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project 491111487 -
                      Open-Access-Publikationskosten / 2022 - 2024 /
                      Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37417432},
      UT           = {WOS:001026974600005},
      doi          = {10.3988/jcn.2022.0302},
      url          = {https://juser.fz-juelich.de/record/1010192},
}