% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Paul:1010193,
      author       = {Paul, Theresa and Wiemer, Valerie M. and Hensel and
                      Cieslak, Matthew and Tscherpel, Caroline and Grefkes,
                      Christian and Grafton, Scott T. and Fink, Gereon Rudolf and
                      Volz, Lukas J.},
      title        = {{I}nterhemispheric {S}tructural {C}onnectivity {U}nderlies
                      {M}otor {R}ecovery after {S}troke},
      journal      = {Annals of neurology},
      volume       = {94},
      number       = {4},
      issn         = {0364-5134},
      address      = {Hoboken, NJ},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2023-03004},
      pages        = {785-797},
      year         = {2023},
      abstract     = {Objective: Although ample evidence highlights that the
                      ipsilesional corticospinal tract (CST) plays a crucial role
                      in motor recovery after stroke, studies on cortico-cortical
                      motor connections remain scarce and provide inconclusive
                      results. Given their unique potential to serve as structural
                      reserve enabling motor network reorganization, the question
                      arises whether cortico-cortical connections may facilitate
                      motor control depending on CST damage.Methods: Diffusion
                      spectrum imaging (DSI) and a novel compartment-wise analysis
                      approach were used to quantify structural connectivity
                      between bilateral cortical core motor regions in chronic
                      stroke patients. Basal and complex motor control were
                      differentially assessed.Results: Both basal and complex
                      motor performance were correlated with structural
                      connectivity between bilateral premotor areas and
                      ipsilesional primary motor cortex (M1) as well as
                      interhemispheric M1 to M1 connectivity. Whereas complex
                      motor skills depended on CST integrity, a strong association
                      between M1 to M1 connectivity and basal motor control was
                      observed independent of CST integrity especially in patients
                      who underwent substantial motor recovery. Harnessing the
                      informational wealth of cortico-cortical connectivity
                      facilitated the explanation of both basal and complex motor
                      control.Interpretation: We demonstrate for the first time
                      that distinct aspects of cortical structural reserve enable
                      basal and complex motor control after stroke. In particular,
                      recovery of basal motor control may be supported via an
                      alternative route through contralesional M1 and non-crossing
                      fibers of the contralesional CST. Our findings help to
                      explain previous conflicting interpretations regarding the
                      functional role of the contralesional M1 and highlight the
                      potential of cortico-cortical structural connectivity as a
                      future biomarker for motor recovery post-stroke. ANN NEUROL
                      2023.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project 431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029) / DFG project
                      491111487 - Open-Access-Publikationskosten / 2022 - 2024 /
                      Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029 /
                      G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37402647},
      UT           = {WOS:001036127300001},
      doi          = {10.1002/ana.26737},
      url          = {https://juser.fz-juelich.de/record/1010193},
}