%0 Journal Article
%A Bloch, Carola
%A Viswanathan, Shivakumar
%A Tepest, Ralf
%A Jording, Mathis
%A Falter-Wagner, Christine M.
%A Vogeley, Kai
%T Differentiated, rather than shared, strategies for time-coordinated action in social and non-social domains in autistic individuals
%J Cortex
%V 166
%@ 0010-9452
%C New York, NY
%I Elsevier
%M FZJ-2023-03005
%P 207 - 232
%D 2023
%X Autism spectrum disorder (ASD) is a neurodevelopmental condition with a highly heterogeneous adult phenotype that includes social and non-social behavioral characteristics. The link between the characteristics assignable to the different domains remains unresolved. One possibility is that social and non-social behaviors in autism are modulated by a common underlying deficit. However, here we report evidence supporting an alternative concept that is individual-centered rather than deficit-centered. Individuals are assumed to have a distinctive style in the strategies they adopt to perform social and non-social tasks with these styles presumably being structured differently between autistic individuals and typically-developed (TD) individuals. We tested this hypothesis for the execution of time-coordinated (synchronized) actions. Participants performed (i) a social task that required synchronized gaze and pointing actions to interact with another person, and (ii) a non-social task that required finger-tapping actions synchronized to periodic stimuli at different time-scales and sensory modalities. In both tasks, synchronization behavior differed between ASD and TD groups. However, a principal component analysis of individual behaviors across tasks revealed associations between social and non-social features for the TD persons but such cross-domain associations were strikingly absent for autistic individuals. The highly differentiated strategies between domains in ASD are inconsistent with a general synchronization deficit and instead highlight the individualized developmental heterogeneity in the acquisition of domain-specific behaviors. We propose a cognitive model to help disentangle individual-centered from deficit-centered effects in other domains. Our findings reinforce the importance to identify individually differentiated phenotypes to personalize autism therapies.Keywords: Adults; Autism; Cross-domain; Neurodevelopmental conditions; Synchronization.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37393703
%U <Go to ISI:>//WOS:001028749100001
%R 10.1016/j.cortex.2023.05.008
%U https://juser.fz-juelich.de/record/1010194