Home > Publications database > KCC2 reverse mode helps to clear postsynaptically released potassium at glutamatergic synapses > print

001     1010486
005     20240226075454.0
024 7 _ |a 10.1016/j.celrep.2023.112934
|2 doi
024 7 _ |a 2211-1247
|2 ISSN
024 7 _ |a 2639-1856
|2 ISSN
024 7 _ |a 10.34734/FZJ-2023-03081
|2 datacite_doi
024 7 _ |a 37537840
|2 pmid
024 7 _ |a WOS:001051595700001
|2 WOS
037 _ _ |a FZJ-2023-03081
082 _ _ |a 610
100 1 _ |a Byvaltcev, Egor
|b 0
245 _ _ |a KCC2 reverse mode helps to clear postsynaptically released potassium at glutamatergic synapses
260 _ _ |a [New York, NY]
|c 2023
|b Elsevier
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1708442075_18657
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a This project has received funding from the EuropeanResearch Council (ERC) under the Union’s Horizon 2020 research an innovation program (grant agreement no. 864243) and from the Einstein FoundationBerlin (EP-2021-621).
520 _ _ |a Extracellular potassium [K+]o elevation during synaptic activity retrogradely modifies presynaptic release and astrocytic uptake of glutamate. Hence, local K+ clearance and replenishment mechanisms are crucial regulators of glutamatergic transmission and plasticity. Based on recordings of astrocytic inward rectifier potassium current IKir and K+-sensitive electrodes as sensors of [K+]o as well as on in silico modeling, we demonstrate that the neuronal K+-Cl- co-transporter KCC2 clears local perisynaptic [K+]o during synaptic excitation by operating in an activity-dependent reversed mode. In reverse mode, KCC2 replenishes K+ in dendritic spines and complements clearance of [K+]o, therewith attenuating presynaptic glutamate release and shortening LTP. We thus demonstrate a physiological role of KCC2 in neuron-glial interactions and regulation of synaptic signaling and plasticity through the uptake of postsynaptically released K+.
536 _ _ |a 5243 - Information Processing in Distributed Systems (POF4-524)
|0 G:(DE-HGF)POF4-5243
|c POF4-524
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de
700 1 _ |a Behbood, Mahraz
|b 1
700 1 _ |a Schleimer, Jan-Hendrik
|b 2
700 1 _ |a Gensch, Thomas
|0 P:(DE-Juel1)131924
|b 3
|u fzj
700 1 _ |a Semyanov, Alexey
|b 4
700 1 _ |a Schreiber, Susanne
|b 5
700 1 _ |a Strauss, Ulf
|0 0000-0002-1534-6624
|b 6
|e Corresponding author
773 _ _ |a 10.1016/j.celrep.2023.112934
|g Vol. 42, no. 8, p. 112934 -
|0 PERI:(DE-600)2649101-1
|n 8
|p 112934 -
|t Cell reports
|v 42
|y 2023
|x 2211-1247
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/Elsevier_Cell_Reports_2023-07-31.pdf
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/1-s2.0-S2211124723009452-main.pdf
|y OpenAccess
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/1-s2.0-S2211124723009452-main.gif?subformat=icon
|x icon
|y OpenAccess
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/1-s2.0-S2211124723009452-main.jpg?subformat=icon-1440
|x icon-1440
|y OpenAccess
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/1-s2.0-S2211124723009452-main.jpg?subformat=icon-180
|x icon-180
|y OpenAccess
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/1-s2.0-S2211124723009452-main.jpg?subformat=icon-640
|x icon-640
|y OpenAccess
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/Elsevier_Cell_Reports_2023-07-31.gif?subformat=icon
|x icon
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/Elsevier_Cell_Reports_2023-07-31.jpg?subformat=icon-1440
|x icon-1440
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/Elsevier_Cell_Reports_2023-07-31.jpg?subformat=icon-180
|x icon-180
856 4 _ |u https://juser.fz-juelich.de/record/1010486/files/Elsevier_Cell_Reports_2023-07-31.jpg?subformat=icon-640
|x icon-640
909 C O |o oai:juser.fz-juelich.de:1010486
|p openaire
|p open_access
|p OpenAPC
|p driver
|p VDB
|p openCost
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 3
|6 P:(DE-Juel1)131924
913 1 _ |a DE-HGF
|b Key Technologies
|l Natural, Artificial and Cognitive Information Processing
|1 G:(DE-HGF)POF4-520
|0 G:(DE-HGF)POF4-524
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-500
|4 G:(DE-HGF)POF
|v Molecular and Cellular Information Processing
|9 G:(DE-HGF)POF4-5243
|x 0
914 1 _ |y 2023
915 p c |a APC keys set
|2 APC
|0 PC:(DE-HGF)0000
915 p c |a DOAJ Journal
|2 APC
|0 PC:(DE-HGF)0003
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2022-11-17
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2022-11-17
915 _ _ |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
|0 LIC:(DE-HGF)CCBYNCND4
|2 HGFVOC
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2022-11-17
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2022-11-17
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2022-11-17
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CELL REP : 2022
|d 2023-10-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-10-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-10-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2023-05-02T08:49:39Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2023-05-02T08:49:39Z
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Anonymous peer review
|d 2023-05-02T08:49:39Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-10-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2023-10-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-10-26
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b CELL REP : 2022
|d 2023-10-26
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)IBI-1-20200312
|k IBI-1
|l Molekular- und Zellphysiologie
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-Juel1)IBI-1-20200312
980 _ _ |a APC
980 _ _ |a UNRESTRICTED
980 1 _ |a APC
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21