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@ARTICLE{Knops:1010516,
      author       = {Knops, Katja and Boldt, Sonja and Wolkenhauer, Olaf and
                      Kriehuber, Ralf},
      title        = {{G}ene {E}xpression in {L}ow- and
                      {H}igh-{D}ose-{I}rradiated {H}uman {P}eripheral {B}lood
                      {L}ymphocytes: {P}ossible {A}pplications for {B}iodosimetry},
      journal      = {Radiation research},
      volume       = {178},
      number       = {4},
      issn         = {0033-7587},
      address      = {Great Falls, Va.},
      publisher    = {Radiation Research Society},
      reportid     = {FZJ-2023-03099},
      pages        = {304 -312},
      year         = {2012},
      abstract     = {To overcome the limitations of existing biodosimetry
                      methods, we examined dose- and time-dependent gene
                      expression changes in human peripheral blood lymphocytes
                      after exposure to low-, medium- and high-dose ionizing
                      radiation and searched for genes suitable for predicting
                      radiation doses in the low-dose range. Additionally, the
                      experiments are intended to provide new insights into the
                      biological effects of exposures to low-, medium- and
                      high-dose radiation. Gene expression analysis using whole
                      human genome DNA microarrays was performed in human blood
                      from six healthy donors irradiated ex vivo with 0, 0.02,
                      0.1, 0.5, 1, 2 and 4 Gy (γ rays, (137)Cs) at 6, 24 and 48 h
                      after high-dose exposure (0.5-4 Gy), and at 24 and 48 h
                      after low-dose exposures of 0.02 or 0.1 Gy. DNA
                      microarray-based alterations in gene expression were found
                      in a wide dose range in vitro and allowed us to identify
                      nine genes with which low radiation doses could be
                      accurately predicted with a sensitivity of $95.6\%.$ In the
                      low-, medium- and high-dose range, expression alterations
                      increased with increasing dose and time after exposure, and
                      were assigned to different biological processes such as
                      nucleosome assembly, apoptosis and DNA repair response. We
                      conclude from our results that gene expression profiles are
                      suitable for predicting low-dose radiation exposure in a
                      rapid and reliable manner and that acute low-dose exposure,
                      as low as 20 mGy, leads to well-defined physiological
                      responses in human peripheral blood lymphocytes.},
      cin          = {S-US},
      ddc          = {530},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF4-899) / Verbundprojekt:
                      Biodosimetrie: Ein systembiologischer Ansatz für die
                      Strahlenbiodosimetrie und die Analyse der individuellen
                      Strahlensensitivität (02NUK005A)},
      pid          = {G:(DE-HGF)POF4-899 / G:(BMBF)02NUK005A},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {22954392},
      UT           = {WOS:000309791000007},
      doi          = {10.1667/RR2913.1},
      url          = {https://juser.fz-juelich.de/record/1010516},
}