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001010518 0247_ $$2doi$$a10.1007/s00411-004-0234-y
001010518 0247_ $$2ISSN$$a0006-3517
001010518 0247_ $$2ISSN$$a0301-634X
001010518 0247_ $$2ISSN$$a1432-2099
001010518 0247_ $$2pmid$$a15106009
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001010518 1001_ $$0P:(DE-Juel1)133469$$aKriehuber, Ralf$$b0$$eCorresponding author$$ufzj
001010518 245__ $$aCytotoxicity, genotoxicity and intracellular distribution of the Auger electron emitter 65 Zn in two human cell lines
001010518 260__ $$aNew York, NY$$bSpringer$$c2004
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001010518 520__ $$aCell survival, induction of apoptosis, and micronucleus formation have been examined in non-transformed human amnion fluid fibroblast-like (AFFL) cells and in a human squameous cell carcinoma (SCL-II) cell line after exposure to the Auger electron emitter (65)Zn and after external low-LET radiation. Cellular uptake and subcellular distribution of (65)Zn(2+) were studied in vitro and the absorbed radiation dose was calculated applying analytical dosimetry models. Auger electrons generated during decay of (65)Zn induced a prominent decrease in cell survival and increased the levels of apoptotic as well as micronucleated cells when compared to external low-LET irradiation. Relative biological effectiveness has been determined for cell survival (RBE approximately 4), micronucleus formation (RBE approximately 2) and apoptosis induction (RBE approximately 5-8) in SCL-II cells and for micronucleus formation (RBE approximately 4-5) and apoptosis induction (RBE approximately 6-10) in AFFL cells, respectively. This demonstrates a general enhanced biological effectiveness of (65)Zn in both investigated cell lines when compared to external low-LET radiation. The distribution pattern of intracellular Zn(2+) was found to be non-uniform, showing enhanced amounts of Zn(2+) in the perinuclear region and low amounts inside the cell nucleus, suggesting a major energy deposition close to the nuclear envelope.
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001010518 7001_ $$0P:(DE-HGF)0$$aRiedling, Manuela$$b1
001010518 7001_ $$0P:(DE-HGF)0$$aSimk�, Myrtill$$b2
001010518 7001_ $$0P:(DE-HGF)0$$aWeiss, Dieter G.$$b3
001010518 773__ $$0PERI:(DE-600)1462083-2$$a10.1007/s00411-004-0234-y$$gVol. 43, no. 1, p. 15 - 22$$n1$$p15 - 22$$tRadiation and environmental biophysics$$v43$$x0006-3517$$y2004
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