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@ARTICLE{Kriehuber:1010518,
      author       = {Kriehuber, Ralf and Riedling, Manuela and Simk�, Myrtill
                      and Weiss, Dieter G.},
      title        = {{C}ytotoxicity, genotoxicity and intracellular distribution
                      of the {A}uger electron emitter 65 {Z}n in two human cell
                      lines},
      journal      = {Radiation and environmental biophysics},
      volume       = {43},
      number       = {1},
      issn         = {0006-3517},
      address      = {New York, NY},
      publisher    = {Springer},
      reportid     = {FZJ-2023-03101},
      pages        = {15 - 22},
      year         = {2004},
      abstract     = {Cell survival, induction of apoptosis, and micronucleus
                      formation have been examined in non-transformed human amnion
                      fluid fibroblast-like (AFFL) cells and in a human squameous
                      cell carcinoma (SCL-II) cell line after exposure to the
                      Auger electron emitter (65)Zn and after external low-LET
                      radiation. Cellular uptake and subcellular distribution of
                      (65)Zn(2+) were studied in vitro and the absorbed radiation
                      dose was calculated applying analytical dosimetry models.
                      Auger electrons generated during decay of (65)Zn induced a
                      prominent decrease in cell survival and increased the levels
                      of apoptotic as well as micronucleated cells when compared
                      to external low-LET irradiation. Relative biological
                      effectiveness has been determined for cell survival (RBE
                      approximately 4), micronucleus formation (RBE approximately
                      2) and apoptosis induction (RBE approximately 5-8) in SCL-II
                      cells and for micronucleus formation (RBE approximately 4-5)
                      and apoptosis induction (RBE approximately 6-10) in AFFL
                      cells, respectively. This demonstrates a general enhanced
                      biological effectiveness of (65)Zn in both investigated cell
                      lines when compared to external low-LET radiation. The
                      distribution pattern of intracellular Zn(2+) was found to be
                      non-uniform, showing enhanced amounts of Zn(2+) in the
                      perinuclear region and low amounts inside the cell nucleus,
                      suggesting a major energy deposition close to the nuclear
                      envelope.},
      cin          = {S-US},
      ddc          = {530},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {15106009},
      UT           = {WOS:000221192400003},
      doi          = {10.1007/s00411-004-0234-y},
      url          = {https://juser.fz-juelich.de/record/1010518},
}