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| Home > Publications database > Cytotoxicity, genotoxicity and intracellular distribution of the Auger electron emitter 65 Zn in two human cell lines > print |
| 001 | 1010518 | ||
| 005 | 20230918092309.0 | ||
| 024 | 7 | _ | |a 10.1007/s00411-004-0234-y |2 doi |
| 024 | 7 | _ | |a 0006-3517 |2 ISSN |
| 024 | 7 | _ | |a 0301-634X |2 ISSN |
| 024 | 7 | _ | |a 1432-2099 |2 ISSN |
| 024 | 7 | _ | |a 15106009 |2 pmid |
| 024 | 7 | _ | |a WOS:000221192400003 |2 WOS |
| 037 | _ | _ | |a FZJ-2023-03101 |
| 082 | _ | _ | |a 530 |
| 100 | 1 | _ | |a Kriehuber, Ralf |0 P:(DE-Juel1)133469 |b 0 |e Corresponding author |u fzj |
| 245 | _ | _ | |a Cytotoxicity, genotoxicity and intracellular distribution of the Auger electron emitter 65 Zn in two human cell lines |
| 260 | _ | _ | |a New York, NY |c 2004 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1692364410_8447 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Cell survival, induction of apoptosis, and micronucleus formation have been examined in non-transformed human amnion fluid fibroblast-like (AFFL) cells and in a human squameous cell carcinoma (SCL-II) cell line after exposure to the Auger electron emitter (65)Zn and after external low-LET radiation. Cellular uptake and subcellular distribution of (65)Zn(2+) were studied in vitro and the absorbed radiation dose was calculated applying analytical dosimetry models. Auger electrons generated during decay of (65)Zn induced a prominent decrease in cell survival and increased the levels of apoptotic as well as micronucleated cells when compared to external low-LET irradiation. Relative biological effectiveness has been determined for cell survival (RBE approximately 4), micronucleus formation (RBE approximately 2) and apoptosis induction (RBE approximately 5-8) in SCL-II cells and for micronucleus formation (RBE approximately 4-5) and apoptosis induction (RBE approximately 6-10) in AFFL cells, respectively. This demonstrates a general enhanced biological effectiveness of (65)Zn in both investigated cell lines when compared to external low-LET radiation. The distribution pattern of intracellular Zn(2+) was found to be non-uniform, showing enhanced amounts of Zn(2+) in the perinuclear region and low amounts inside the cell nucleus, suggesting a major energy deposition close to the nuclear envelope. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de |
| 700 | 1 | _ | |a Riedling, Manuela |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Simk�, Myrtill |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Weiss, Dieter G. |0 P:(DE-HGF)0 |b 3 |
| 773 | _ | _ | |a 10.1007/s00411-004-0234-y |g Vol. 43, no. 1, p. 15 - 22 |0 PERI:(DE-600)1462083-2 |n 1 |p 15 - 22 |t Radiation and environmental biophysics |v 43 |y 2004 |x 0006-3517 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1010518/files/s00411-004-0234-y.pdf |
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