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@ARTICLE{Kriehuber:1010519,
      author       = {Kriehuber, Ralf and Simkó, Myrtill},
      title        = {{A}poptosis {I}nduction and {M}icronucleus {F}ormation
                      after {E}xposure to the {A}uger {E}lectron {E}mitter
                      {Z}inc-65 in a {H}uman {C}ell {L}ine},
      journal      = {Acta oncologica},
      volume       = {39},
      number       = {6},
      issn         = {0284-186X},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {FZJ-2023-03102},
      pages        = {699 - 706},
      year         = {2000},
      abstract     = {Induction of apoptosis and micronucleus formation has been
                      studied in a transformed human squamous cell carcinoma cell
                      line (SCL-II) after exposure to the Auger electron emitter
                      Zinc-65 (65Zn) and after external low-LET radiation.
                      Exposure to non-radioactive Zn and unirradiated cells served
                      as controls. Studies on the cellular uptake of 65Zn2+ have
                      been carried out in vitro and conventional dosimetric models
                      have been applied to derive the absorbed radiation dose.
                      Auger electrons, generated during decay of 65Zn2+, are
                      strong inducers of micronuclei as well as of apoptosis, in
                      comparison to external low-LET irradiation. The relative
                      biological effectiveness has been determined and was found
                      to be in the range of 1.2-2.7 for the two investigated
                      biological endpoints, depending on which mathematical model
                      for describing the dose-effect curves was used. A
                      non-uniform distribution of intracellular Zn2 + was
                      observed, showing a strong signal in the perinuclear region.
                      We conclude that separate radiation weighting factors for
                      Auger electrons should be established depending on the
                      nuclide and its ability to interact with the DNA (e.g. 65Zn
                      by Zinc-finger proteins)},
      cin          = {S-US},
      ddc          = {610},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {11130007},
      UT           = {WOS:000165549800008},
      doi          = {10.1080/028418600750063758},
      url          = {https://juser.fz-juelich.de/record/1010519},
}