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@ARTICLE{Kriehuber:1010520,
      author       = {Kriehuber, Ralf and Simko, M and Schiffmann, D. and Trott,
                      K.-R.},
      title        = {{D}elayed cytotoxic and genotoxic effects in a human cell
                      line following {X}-irradiation},
      journal      = {International journal of radiation biology},
      volume       = {75},
      number       = {8},
      issn         = {0020-7616},
      address      = {Abingdon},
      publisher    = {Informa Healthcare},
      reportid     = {FZJ-2023-03103},
      pages        = {1021 - 1027},
      year         = {1999},
      abstract     = {Background: In order to clarify the relationship between
                      delayed reproductive death and radiation-induced genomic
                      instability, the colony-forming efficiency of surviving,
                      irradiated human squamous carcinoma cells and centromere
                      positive as well as centromere negative micronuclei in
                      surviving progeny were examined.Materials and methods:
                      Colony-forming ability and micronucleus (MN) frequency in
                      binucleated cells 24 h after the addition of cytochalasin B
                      during 2 weeks of post-irradiation growth were determined in
                      a squamous cell carcinoma cell line (SCL-II) of human
                      origin. In addition, centromeres in micronuclei were
                      detected using FISH.Results: In the human epithelial cell
                      line used for these experiments, delayed reproductive death
                      was pronounced and persisted for at least 2 weeks after
                      irradiation. Although there is evidence for an increased
                      rate of centromere positive micronuclei, but not of
                      centromere negative micronuclei, arising during the first
                      week of post-irradiation proliferation, this decreases later
                      while the rate of delayed reproductive death remains
                      elevated.Conclusion: In the studied cell line, the observed
                      delayed reproductive death is not closely related to the
                      investigated criteria of radiation-induced genomic
                      instability. This casts doubt on the common assumption that
                      delayed reproductive death is a direct manifestation of
                      radiation-induced genomic instability.},
      cin          = {S-US},
      ddc          = {570},
      cid          = {I:(DE-Juel1)S-US-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1080/095530099139782},
      url          = {https://juser.fz-juelich.de/record/1010520},
}