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| Hauptseite > Publikationsdatenbank > Delayed cytotoxic and genotoxic effects in a human cell line following X-irradiation > print |
| Hauptseite > Publikationsdatenbank > Delayed cytotoxic and genotoxic effects in a human cell line following X-irradiation > print |
| 001 | 1010520 | ||
| 005 | 20230818204409.0 | ||
| 024 | 7 | _ | |a 10.1080/095530099139782 |2 doi |
| 024 | 7 | _ | |a 0020-7616 |2 ISSN |
| 024 | 7 | _ | |a 0955-3002 |2 ISSN |
| 024 | 7 | _ | |a 1362-3095 |2 ISSN |
| 037 | _ | _ | |a FZJ-2023-03103 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Kriehuber, Ralf |0 P:(DE-Juel1)133469 |b 0 |e Corresponding author |u fzj |
| 245 | _ | _ | |a Delayed cytotoxic and genotoxic effects in a human cell line following X-irradiation |
| 260 | _ | _ | |a Abingdon |c 1999 |b Informa Healthcare |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1692357272_8447 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Background: In order to clarify the relationship between delayed reproductive death and radiation-induced genomic instability, the colony-forming efficiency of surviving, irradiated human squamous carcinoma cells and centromere positive as well as centromere negative micronuclei in surviving progeny were examined.Materials and methods: Colony-forming ability and micronucleus (MN) frequency in binucleated cells 24 h after the addition of cytochalasin B during 2 weeks of post-irradiation growth were determined in a squamous cell carcinoma cell line (SCL-II) of human origin. In addition, centromeres in micronuclei were detected using FISH.Results: In the human epithelial cell line used for these experiments, delayed reproductive death was pronounced and persisted for at least 2 weeks after irradiation. Although there is evidence for an increased rate of centromere positive micronuclei, but not of centromere negative micronuclei, arising during the first week of post-irradiation proliferation, this decreases later while the rate of delayed reproductive death remains elevated.Conclusion: In the studied cell line, the observed delayed reproductive death is not closely related to the investigated criteria of radiation-induced genomic instability. This casts doubt on the common assumption that delayed reproductive death is a direct manifestation of radiation-induced genomic instability. |
| 536 | _ | _ | |a 899 - ohne Topic (POF4-899) |0 G:(DE-HGF)POF4-899 |c POF4-899 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de |
| 700 | 1 | _ | |a Simko, M |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Schiffmann, D. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Trott, K.-R. |0 P:(DE-HGF)0 |b 3 |
| 773 | _ | _ | |a 10.1080/095530099139782 |g Vol. 75, no. 8, p. 1021 - 1027 |0 PERI:(DE-600)3065-X |n 8 |p 1021 - 1027 |t International journal of radiation biology |v 75 |y 1999 |x 0020-7616 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1010520/files/Delayed%20cytotoxic%20and%20genotoxic%20effects%20in%20a%20human%20cell%20line%20following%20X%20irradiation.pdf |
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| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)133469 |
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| 920 | 1 | _ | |0 I:(DE-Juel1)S-US-20090406 |k S-US |l Sicherheit und Strahlenschutz, Umgebungsüberwachung,Strahlenbiologie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)S-US-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
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