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001014215 1001_ $$0P:(DE-HGF)0$$aBehfar, Qumars$$b0
001014215 245__ $$aImproved connectivity and cognition due to cognitive stimulation in Alzheimer’s disease
001014215 260__ $$aLausanne$$bFrontiers Research Foundation$$c2023
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001014215 520__ $$aBackground: Due to the increasing prevalence of Alzheimer’s disease (AD) and the limited efficacy of pharmacological treatment, the interest in non-pharmacological interventions, e.g., cognitive stimulation therapy (CST), to improve cognitive dysfunction and the quality of life of AD patients are on a steady rise.Objectives: Here, we examined the efficacy of a CST program specifically conceptualized for AD dementia patients and the neural mechanisms underlying cognitive or behavioral benefits of CST.Methods: Using neuropsychological tests and MRI-based measurements of functional connectivity, we examined the (neuro-) psychological status and network changes at two time points: pre vs. post-stimulation (8 to 12 weeks) in the intervention group (n = 15) who received the CST versus a no-intervention control group (n = 15).Results: After CST, we observed significant improvement in the Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale, cognitive subsection (ADAS-cog), and the behavioral and psychological symptoms of dementia (BPSD) scores. These cognitive improvements were associated with an up-regulated functional connectivity between the left posterior hippocampus and the trunk of the left postcentral gyrus.Conclusion: Our data indicate that CST seems to induce short-term global cognition and behavior improvements in mild to moderate AD dementia and enhances resting-state functional connectivity in learning- and memory-associated brain regions. These convergent results prove that even in mild to moderate dementia AD, neuroplasticity can be harnessed to alleviate cognitive impairment with CST.
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001014215 7001_ $$aRichter, Nils$$b1
001014215 7001_ $$0P:(DE-HGF)0$$aKural, Merve$$b2
001014215 7001_ $$0P:(DE-HGF)0$$aClemens, Anne$$b3
001014215 7001_ $$0P:(DE-HGF)0$$aBehfar, Stefan Kambiz$$b4
001014215 7001_ $$0P:(DE-HGF)0$$aFolkerts, Ann-Kristin$$b5
001014215 7001_ $$0P:(DE-HGF)0$$aFassbender, Ronja$$b6
001014215 7001_ $$0P:(DE-HGF)0$$aKalbe, Elke$$b7
001014215 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b8$$ufzj
001014215 7001_ $$0P:(DE-HGF)0$$aOnur, Oezguer A.$$b9$$eCorresponding author
001014215 773__ $$0PERI:(DE-600)2558898-9$$a10.3389/fnagi.2023.1140975$$gVol. 15, p. 1140975$$p1140975$$tFrontiers in aging neuroscience$$v15$$x1663-4365$$y2023
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