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@ARTICLE{Behfar:1014215,
      author       = {Behfar, Qumars and Richter, Nils and Kural, Merve and
                      Clemens, Anne and Behfar, Stefan Kambiz and Folkerts,
                      Ann-Kristin and Fassbender, Ronja and Kalbe, Elke and Fink,
                      Gereon R. and Onur, Oezguer A.},
      title        = {{I}mproved connectivity and cognition due to cognitive
                      stimulation in {A}lzheimer’s disease},
      journal      = {Frontiers in aging neuroscience},
      volume       = {15},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2023-03199},
      pages        = {1140975},
      year         = {2023},
      abstract     = {Background: Due to the increasing prevalence of
                      Alzheimer’s disease (AD) and the limited efficacy of
                      pharmacological treatment, the interest in
                      non-pharmacological interventions, e.g., cognitive
                      stimulation therapy (CST), to improve cognitive dysfunction
                      and the quality of life of AD patients are on a steady
                      rise.Objectives: Here, we examined the efficacy of a CST
                      program specifically conceptualized for AD dementia patients
                      and the neural mechanisms underlying cognitive or behavioral
                      benefits of CST.Methods: Using neuropsychological tests and
                      MRI-based measurements of functional connectivity, we
                      examined the (neuro-) psychological status and network
                      changes at two time points: pre vs. post-stimulation (8 to
                      12 weeks) in the intervention group (n = 15) who received
                      the CST versus a no-intervention control group (n =
                      15).Results: After CST, we observed significant improvement
                      in the Mini-Mental State Examination (MMSE), the
                      Alzheimer’s Disease Assessment Scale, cognitive subsection
                      (ADAS-cog), and the behavioral and psychological symptoms of
                      dementia (BPSD) scores. These cognitive improvements were
                      associated with an up-regulated functional connectivity
                      between the left posterior hippocampus and the trunk of the
                      left postcentral gyrus.Conclusion: Our data indicate that
                      CST seems to induce short-term global cognition and behavior
                      improvements in mild to moderate AD dementia and enhances
                      resting-state functional connectivity in learning- and
                      memory-associated brain regions. These convergent results
                      prove that even in mild to moderate dementia AD,
                      neuroplasticity can be harnessed to alleviate cognitive
                      impairment with CST.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project 491111487 -
                      Open-Access-Publikationskosten / 2022 - 2024 /
                      Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37662551},
      UT           = {WOS:001059162300001},
      doi          = {10.3389/fnagi.2023.1140975},
      url          = {https://juser.fz-juelich.de/record/1014215},
}