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024 7 _ |a 10.3389/fnagi.2023.1140975
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100 1 _ |a Behfar, Qumars
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245 _ _ |a Improved connectivity and cognition due to cognitive stimulation in Alzheimer’s disease
260 _ _ |a Lausanne
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520 _ _ |a Background: Due to the increasing prevalence of Alzheimer’s disease (AD) and the limited efficacy of pharmacological treatment, the interest in non-pharmacological interventions, e.g., cognitive stimulation therapy (CST), to improve cognitive dysfunction and the quality of life of AD patients are on a steady rise.Objectives: Here, we examined the efficacy of a CST program specifically conceptualized for AD dementia patients and the neural mechanisms underlying cognitive or behavioral benefits of CST.Methods: Using neuropsychological tests and MRI-based measurements of functional connectivity, we examined the (neuro-) psychological status and network changes at two time points: pre vs. post-stimulation (8 to 12 weeks) in the intervention group (n = 15) who received the CST versus a no-intervention control group (n = 15).Results: After CST, we observed significant improvement in the Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale, cognitive subsection (ADAS-cog), and the behavioral and psychological symptoms of dementia (BPSD) scores. These cognitive improvements were associated with an up-regulated functional connectivity between the left posterior hippocampus and the trunk of the left postcentral gyrus.Conclusion: Our data indicate that CST seems to induce short-term global cognition and behavior improvements in mild to moderate AD dementia and enhances resting-state functional connectivity in learning- and memory-associated brain regions. These convergent results prove that even in mild to moderate dementia AD, neuroplasticity can be harnessed to alleviate cognitive impairment with CST.
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700 1 _ |a Richter, Nils
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700 1 _ |a Kural, Merve
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700 1 _ |a Clemens, Anne
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700 1 _ |a Behfar, Stefan Kambiz
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700 1 _ |a Folkerts, Ann-Kristin
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700 1 _ |a Fassbender, Ronja
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700 1 _ |a Kalbe, Elke
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700 1 _ |a Fink, Gereon R.
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700 1 _ |a Onur, Oezguer A.
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773 _ _ |a 10.3389/fnagi.2023.1140975
|g Vol. 15, p. 1140975
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|t Frontiers in aging neuroscience
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856 4 _ |u https://juser.fz-juelich.de/record/1014215/files/fnagi-15-1140975.pdf
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