001014930 001__ 1014930
001014930 005__ 20231027114415.0
001014930 0247_ $$2doi$$a10.1093/cercor/bhad273
001014930 0247_ $$2ISSN$$a1047-3211
001014930 0247_ $$2ISSN$$a1460-2199
001014930 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-03485
001014930 0247_ $$2pmid$$a37540164
001014930 0247_ $$2WOS$$aWOS:001040415400001
001014930 037__ $$aFZJ-2023-03485
001014930 082__ $$a610
001014930 1001_ $$0P:(DE-Juel1)177822$$aPaas Oliveros, Lya K$$b0$$eCorresponding author
001014930 245__ $$aBrain functional characterization of response-code conflict in dual-tasking and its modulation by age
001014930 260__ $$aOxford$$bOxford Univ. Press$$c2023
001014930 3367_ $$2DRIVER$$aarticle
001014930 3367_ $$2DataCite$$aOutput Types/Journal article
001014930 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1696419932_8505
001014930 3367_ $$2BibTeX$$aARTICLE
001014930 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001014930 3367_ $$00$$2EndNote$$aJournal Article
001014930 500__ $$aThis study was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, LA 3071/3-1, SFB 1451), the National Institute of Mental Health (R01-MH074457), the Helmholtz Portfolio Theme Supercomputing and Modeling for the Human Brain, and the European Union’s Horizon 2020 Research and Innovation Program under Grant Agreements 720270 (HBP SGA1), 785907 (HBP SGA2).
001014930 520__ $$aCrosstalk between conflicting response codes contributes to interference in dual-tasking, an effect exacerbated in advanced age. Here, we investigated (i) brain activity correlates of such response-code conflicts, (ii) activity modulations by individual dual-task performance and related cognitive abilities, (iii) task-modulated connectivity within the task network, and (iv) age-related differences in all these aspects. Young and older adults underwent fMRI while responding to the pitch of tones through spatially mapped speeded button presses with one or two hands concurrently. Using opposing stimulus–response mappings between hands, we induced conflict between simultaneously activated response codes. These response-code conflicts elicited activation in key regions of the multiple-demand network. While thalamic and parietal areas of the conflict-related network were modulated by attentional, working-memory and task-switching abilities, efficient conflict resolution in dual-tasking mainly relied on increasing supplementary motor activity. Older adults showed non-compensatory hyperactivity in left superior frontal gyrus, and higher right premotor activity was modulated by working-memory capacity. Finally, connectivity between premotor or parietal seed regions and the conflict-sensitive network was neither conflict-specific nor age-sensitive. Overall, resolving dual-task response-code conflict recruited substantial parts of the multiple-demand network, whose activity and coupling, however, were only little affected by individual differences in task performance or age.
001014930 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001014930 588__ $$aDataset connected to DataCite
001014930 7001_ $$0P:(DE-Juel1)131855$$aCieslik, Edna$$b1$$ufzj
001014930 7001_ $$0P:(DE-HGF)0$$aPieczykolan, Aleks$$b2
001014930 7001_ $$0P:(DE-Juel1)161305$$aPläschke, Rachel N$$b3
001014930 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B$$b4
001014930 7001_ $$0P:(DE-Juel1)131693$$aLangner, Robert$$b5
001014930 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhad273$$gp. bhad273$$n18$$p10155–10180$$tCerebral cortex$$v33$$x1047-3211$$y2023
001014930 8564_ $$uhttps://juser.fz-juelich.de/record/1014930/files/E16293607.pdf
001014930 8564_ $$uhttps://juser.fz-juelich.de/record/1014930/files/Paas_Brain_functioning_dual-tasking_aging_R1_FINAL.docx$$yOpenAccess
001014930 8564_ $$uhttps://juser.fz-juelich.de/record/1014930/files/Paas_Brain_functioning_dual-tasking_aging_SupplMat_R1_FINAL.docx$$yOpenAccess
001014930 8564_ $$uhttps://juser.fz-juelich.de/record/1014930/files/Paas_Brain_functioning_dual-tasking_aging_R1_FINAL%281%29.pdf$$yOpenAccess
001014930 8767_ $$8E16293607$$92023-09-04$$a1200197352$$d2023-10-20$$ePage charges$$jZahlung erfolgt
001014930 8767_ $$8E16293607$$92023-09-04$$a1200197352$$d2023-10-20$$eColour charges$$jZahlung erfolgt
001014930 909CO $$ooai:juser.fz-juelich.de:1014930$$pdnbdelivery$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire
001014930 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177822$$aForschungszentrum Jülich$$b0$$kFZJ
001014930 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)177822$$a HHU Düsseldorf$$b0
001014930 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131855$$aForschungszentrum Jülich$$b1$$kFZJ
001014930 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131855$$a HHU Düsseldorf$$b1
001014930 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b4$$kFZJ
001014930 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131678$$a HHU Düsseldorf$$b4
001014930 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131693$$aForschungszentrum Jülich$$b5$$kFZJ
001014930 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131693$$a HHU Düsseldorf$$b5
001014930 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001014930 9141_ $$y2023
001014930 915pc $$0PC:(DE-HGF)0000$$2APC$$aAPC keys set
001014930 915pc $$0PC:(DE-HGF)0001$$2APC$$aLocal Funding
001014930 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-11
001014930 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-11
001014930 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001014930 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-11
001014930 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-08-23$$wger
001014930 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCEREB CORTEX : 2022$$d2023-08-23
001014930 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-23
001014930 920__ $$lyes
001014930 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
001014930 980__ $$ajournal
001014930 980__ $$aVDB
001014930 980__ $$aUNRESTRICTED
001014930 980__ $$aI:(DE-Juel1)INM-7-20090406
001014930 980__ $$aAPC
001014930 9801_ $$aAPC
001014930 9801_ $$aFullTexts