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@ARTICLE{PaasOliveros:1014930,
      author       = {Paas Oliveros, Lya K and Cieslik, Edna and Pieczykolan,
                      Aleks and Pläschke, Rachel N and Eickhoff, Simon B and
                      Langner, Robert},
      title        = {{B}rain functional characterization of response-code
                      conflict in dual-tasking and its modulation by age},
      journal      = {Cerebral cortex},
      volume       = {33},
      number       = {18},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2023-03485},
      pages        = {10155–10180},
      year         = {2023},
      note         = {This study was supported by the Deutsche
                      Forschungsgemeinschaft (DFG, German Research Foundation, LA
                      3071/3-1, SFB 1451), the National Institute of Mental Health
                      (R01-MH074457), the Helmholtz Portfolio Theme Supercomputing
                      and Modeling for the Human Brain, and the European Union’s
                      Horizon 2020 Research and Innovation Program under Grant
                      Agreements 720270 (HBP SGA1), 785907 (HBP SGA2).},
      abstract     = {Crosstalk between conflicting response codes contributes to
                      interference in dual-tasking, an effect exacerbated in
                      advanced age. Here, we investigated (i) brain activity
                      correlates of such response-code conflicts, (ii) activity
                      modulations by individual dual-task performance and related
                      cognitive abilities, (iii) task-modulated connectivity
                      within the task network, and (iv) age-related differences in
                      all these aspects. Young and older adults underwent fMRI
                      while responding to the pitch of tones through spatially
                      mapped speeded button presses with one or two hands
                      concurrently. Using opposing stimulus–response mappings
                      between hands, we induced conflict between simultaneously
                      activated response codes. These response-code conflicts
                      elicited activation in key regions of the multiple-demand
                      network. While thalamic and parietal areas of the
                      conflict-related network were modulated by attentional,
                      working-memory and task-switching abilities, efficient
                      conflict resolution in dual-tasking mainly relied on
                      increasing supplementary motor activity. Older adults showed
                      non-compensatory hyperactivity in left superior frontal
                      gyrus, and higher right premotor activity was modulated by
                      working-memory capacity. Finally, connectivity between
                      premotor or parietal seed regions and the conflict-sensitive
                      network was neither conflict-specific nor age-sensitive.
                      Overall, resolving dual-task response-code conflict
                      recruited substantial parts of the multiple-demand network,
                      whose activity and coupling, however, were only little
                      affected by individual differences in task performance or
                      age.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37540164},
      UT           = {WOS:001040415400001},
      doi          = {10.1093/cercor/bhad273},
      url          = {https://juser.fz-juelich.de/record/1014930},
}