% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Bueno:1015426,
      author       = {Bueno, Diones and Narayan Dey, Partha and Schacht, Teresa
                      and Wolf, Christina and Wüllner, Verena and Morpurgo, Elena
                      and Rojas-Charry, Liliana and Sessinghaus, Lena and Leukel,
                      Petra and Sommer, Clemens and Radyushkin, Konstantin and
                      Florin, Luise and Baumgart, Jan and Stamm, Paul and Daiber,
                      Andreas and Horta, Guilherme and Nardi, Leonardo and Vasic,
                      Verica and Schmeisser, Michael J. and Hellwig, Andrea and
                      Oskamp, Angela and Bauer, Andreas and Anand, Ruchika and
                      Reichert, Andreas S. and Ritz, Sandra and Nocera, Gianluigi
                      and Jacob, Claire and Peper, Jonas and Silies, Marion and
                      Frauenknecht, Katrin B. M. and Schäfer, Michael K. E. and
                      Methner, Axel},
      title        = {{NECAB}2 is an endosomal protein important for striatal
                      function},
      journal      = {Free radical biology and medicine},
      volume       = {208},
      issn         = {0891-5849},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2023-03683},
      pages        = {643 - 656},
      year         = {2023},
      note         = {Postprint liegt mir aktuell leider nicht vor},
      abstract     = {Synaptic signaling depends on ATP generated by
                      mitochondria. Dysfunctional mitochondria shift the redox
                      balance towards a more oxidative environment. Due to
                      extensive connectivity, the striatum is especially
                      vulnerable to mitochondrial dysfunction. We found that
                      neuronal calcium-binding protein 2 (NECAB2) plays a role in
                      striatal function and mitochondrial homeostasis. NECAB2 is a
                      predominantly endosomal striatal protein which partially
                      colocalizes with mitochondria. This colocalization is
                      enhanced by mild oxidative stress. Global knockout of Necab2
                      in the mouse results in increased superoxide levels,
                      increased DNA oxidation and reduced levels of the
                      antioxidant glutathione which correlates with an altered
                      mitochondrial shape and function. Striatal mitochondria from
                      Necab2 knockout mice are more abundant and smaller and
                      characterized by a reduced spare capacity suggestive of
                      intrinsic uncoupling respectively mitochondrial dysfunction.
                      In line with this, we also found an altered stress-induced
                      interaction of endosomes with mitochondria in Necab2
                      knockout striatal cultures. The predominance of
                      dysfunctional mitochondria and the pro-oxidative redox
                      milieu correlates with a loss of striatal synapses and
                      behavioral changes characteristic of striatal dysfunction
                      like reduced motivation and altered sensory gating. Together
                      this suggests an involvement of NECAB2 in an endosomal
                      pathway of mitochondrial stress response important for
                      striatal function.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5252 - Brain Dysfunction
                      and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37722569},
      UT           = {WOS:001083542200001},
      doi          = {10.1016/j.freeradbiomed.2023.09.003},
      url          = {https://juser.fz-juelich.de/record/1015426},
}