TY  - JOUR
AU  - Turker, Sabrina
AU  - Kuhnke, Philipp
AU  - Eickhoff, Simon B.
AU  - Caspers, Svenja
AU  - Hartwigsen, Gesa
TI  - Cortical, subcortical, and cerebellar contributions to language processing: A meta-analytic review of 403 neuroimaging experiments.
JO  - Psychological bulletin
VL  - 149
IS  - 11-12
SN  - 0033-2909
PB  - PsycArticles
M1  - FZJ-2023-03697
SP  - 699-723
PY  - 2023
AB  - Language is a key human faculty for communication and interaction that provides invaluable insight into the human mind. Previous work has dissected different linguistic operations, but the large-scale brain networks involved in language processing are still not fully uncovered. Particularly, little is known about the subdomain-specific engagement of brain areas during semantic, syntactic, phonological, and prosodic processing and the role of subcortical and cerebellar areas. Here, we present the largest coordinate-based meta-analysis of language processing including 403 experiments. Overall, language processing primarily engaged bilateral fronto-temporal cortices, with the highest activation likelihood in the left posterior inferior frontal gyrus (IFG). Whereas we could not detect any syntax-specific regions, semantics specifically engaged left posterior temporal areas (left fusiform and occipitotemporal cortex) and the left frontal pole. Phonology showed highest subdomain-specificity in bilateral auditory and left postcentral regions, whereas prosody engaged specifically the right amygdala and the right IFG. Across all subdomains and modalities, we found strong bilateral subcortical and cerebellar contributions. Especially the right cerebellum was engaged during various processes, including speech production, visual, and phonological tasks. Collectively, our results emphasize consistent recruitment and high functional modularity for general language processing in bilateral domain-specific (temporo-frontal) and domain-general (medial frontal/anterior cingulate cortex) regions but also a high specialization of different subareas for different linguistic subdomains. Our findings refine current neurobiological models of language by adding novel insight into the general sensitivity of the language network and subdomain-specific functions of different brain areas and highlighting the role of subcortical and cerebellar regions for different language operations.
LB  - PUB:(DE-HGF)16
C6  - 37768610
UR  - <Go to ISI:>//WOS:001108569000001
DO  - DOI:10.1037/bul0000403
UR  - https://juser.fz-juelich.de/record/1016531
ER  -