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@ARTICLE{Turker:1016531,
author = {Turker, Sabrina and Kuhnke, Philipp and Eickhoff, Simon B.
and Caspers, Svenja and Hartwigsen, Gesa},
title = {{C}ortical, subcortical, and cerebellar contributions to
language processing: {A} meta-analytic review of 403
neuroimaging experiments.},
journal = {Psychological bulletin},
volume = {149},
number = {11-12},
issn = {0033-2909},
publisher = {PsycArticles},
reportid = {FZJ-2023-03697},
pages = {699-723},
year = {2023},
abstract = {Language is a key human faculty for communication and
interaction that provides invaluable insight into the human
mind. Previous work has dissected different linguistic
operations, but the large-scale brain networks involved in
language processing are still not fully uncovered.
Particularly, little is known about the subdomain-specific
engagement of brain areas during semantic, syntactic,
phonological, and prosodic processing and the role of
subcortical and cerebellar areas. Here, we present the
largest coordinate-based meta-analysis of language
processing including 403 experiments. Overall, language
processing primarily engaged bilateral fronto-temporal
cortices, with the highest activation likelihood in the left
posterior inferior frontal gyrus (IFG). Whereas we could not
detect any syntax-specific regions, semantics specifically
engaged left posterior temporal areas (left fusiform and
occipitotemporal cortex) and the left frontal pole.
Phonology showed highest subdomain-specificity in bilateral
auditory and left postcentral regions, whereas prosody
engaged specifically the right amygdala and the right IFG.
Across all subdomains and modalities, we found strong
bilateral subcortical and cerebellar contributions.
Especially the right cerebellum was engaged during various
processes, including speech production, visual, and
phonological tasks. Collectively, our results emphasize
consistent recruitment and high functional modularity for
general language processing in bilateral domain-specific
(temporo-frontal) and domain-general (medial
frontal/anterior cingulate cortex) regions but also a high
specialization of different subareas for different
linguistic subdomains. Our findings refine current
neurobiological models of language by adding novel insight
into the general sensitivity of the language network and
subdomain-specific functions of different brain areas and
highlighting the role of subcortical and cerebellar regions
for different language operations.},
cin = {INM-7},
ddc = {150},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5254 - Neuroscientific Data Analytics and AI (POF4-525)},
pid = {G:(DE-HGF)POF4-5254},
typ = {PUB:(DE-HGF)16},
pubmed = {37768610},
UT = {WOS:001108569000001},
doi = {10.1037/bul0000403},
url = {https://juser.fz-juelich.de/record/1016531},
}