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@ARTICLE{Hu:1016762,
      author       = {Hu, Ziheng and Zhu, Ruifeng and Figueroa-Miranda, Gabriela
                      and Zhou, Lei and Feng, Lingyan and Offenhäusser, Andreas
                      and Mayer, Dirk},
      title        = {{T}runcated {E}lectrochemical {A}ptasensor with {E}nhanced
                      {A}ntifouling {C}apability for {H}ighly {S}ensitive
                      {S}erotonin {D}etection},
      journal      = {Biosensors},
      volume       = {13},
      number       = {9},
      issn         = {2079-6374},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2023-03748},
      pages        = {881 -},
      year         = {2023},
      abstract     = {Accurate determination of serotonin (ST) provides insight
                      into neurological processes and enables applications in
                      clinical diagnostics of brain diseases. Herein, we present
                      an electrochemical aptasensor based on truncated DNA
                      aptamers and a polyethylene glycol (PEG)
                      molecule-functionalized sensing interface for highly
                      sensitive and selective ST detection. The truncated aptamers
                      have a small size and adopt a stable stem-loop
                      configuration, which improves the accessibility of the
                      aptamer for the analyte and enhances the sensitivity of the
                      aptasensor. Upon target binding, these aptamers perform a
                      conformational change, leading to a variation in the Faraday
                      current of the redox tag, which was recorded by square wave
                      voltammetry (SWV). Using PEG as blocking molecules minimizes
                      nonspecific adsorption of other interfering molecules and
                      thus endows an enhanced antifouling ability. The proposed
                      electrochemical aptamer sensor showed a wide range of
                      detection lasting from 0.1 nM to 1000 nM with a low limit of
                      detection of 0.14 nM. Owing to the unique properties of
                      aptamer receptors, the aptasensor also exhibits high
                      selectivity and stability. Furthermore, with the reduced
                      unspecific adsorption, assaying of ST in human serum and
                      artificial cerebrospinal fluid (aCSF) showed excellent
                      performance. The reported strategy of utilizing antifouling
                      PEG describes a novel approach to building antifouling
                      aptasensors and holds great potential for neurochemical
                      investigations and clinical diagnosis},
      cin          = {IBI-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37754115},
      UT           = {WOS:001075035300001},
      doi          = {10.3390/bios13090881},
      url          = {https://juser.fz-juelich.de/record/1016762},
}