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001016976 245__ $$aCryo-EM of Aβ Fibrils from Mouse Models find tg-APPArcSwe fibrils resemble those found in sporadic Alzheimer's disease patients
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001016976 520__ $$aThe use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for the preclinical assessment of new treatment strategies for Alzheimer's disease. However, the properties of Aβ in such mice have not been systematically compared to Aβ in the brains of patients with Alzheimer's disease. Here, we determined the structures of nine ex vivo Aβ fibrils from six different mouse models by cryogenic-electron microscopy. We found novel Aβ fibril structures in the APP/PS1, ARTE10 and tg-SwDI models, whereas the human type II filament fold was found in the ARTE10, tg-APPSwe and APP23 models. The tg-APPArcSwe mice showed an Aβ fibril whose structure resembles the human type I filament found in patients with sporadic Alzheimer's disease. A detailed assessment of the Aβ fibril structure is key to the selection of adequate mouse models for the preclinical development of novel plaque-targeting therapeutics and positron emission tomography imaging tracers in Alzheimer's disease.
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001016976 7001_ $$0P:(DE-Juel1)201266$$aPeralta Reyes, Fernanda$$b1
001016976 7001_ $$0P:(DE-Juel1)145165$$aGremer, Lothar$$b2$$eCorresponding author
001016976 7001_ $$0P:(DE-Juel1)165908$$aSchemmert, Sarah$$b3
001016976 7001_ $$0P:(DE-Juel1)172887$$aFrieg, Benedikt$$b4
001016976 7001_ $$0P:(DE-Juel1)178773$$aSchäfer, Luisa$$b5
001016976 7001_ $$0P:(DE-Juel1)144347$$aWilluweit, Antje$$b6
001016976 7001_ $$0P:(DE-HGF)0$$aDonner, Lili$$b7
001016976 7001_ $$0P:(DE-HGF)0$$aElvers, Margitta$$b8
001016976 7001_ $$0P:(DE-HGF)0$$aNilsson, Lars N. G.$$b9
001016976 7001_ $$0P:(DE-HGF)0$$aSyvänen, Stina$$b10
001016976 7001_ $$0P:(DE-HGF)0$$aSehlin, Dag$$b11
001016976 7001_ $$0P:(DE-HGF)0$$aIngelsson, Martin$$b12
001016976 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b13$$eCorresponding author
001016976 7001_ $$0P:(DE-Juel1)132018$$aSchröder, Gunnar$$b14$$eCorresponding author
001016976 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-023-01484-4$$p2073-2080$$tNature neuroscience$$v26$$x1097-6256$$y2023
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