TY  - JOUR
AU  - Zielinski, Mara
AU  - Peralta Reyes, Fernanda
AU  - Gremer, Lothar
AU  - Schemmert, Sarah
AU  - Frieg, Benedikt
AU  - Schäfer, Luisa
AU  - Willuweit, Antje
AU  - Donner, Lili
AU  - Elvers, Margitta
AU  - Nilsson, Lars N. G.
AU  - Syvänen, Stina
AU  - Sehlin, Dag
AU  - Ingelsson, Martin
AU  - Willbold, Dieter
AU  - Schröder, Gunnar
TI  - Cryo-EM of Aβ Fibrils from Mouse Models find tg-APPArcSwe fibrils resemble those found in sporadic Alzheimer's disease patients
JO  - Nature neuroscience
VL  - 26
SN  - 1097-6256
CY  - New York, NY
PB  - Nature America
M1  - FZJ-2023-03883
SP  - 2073-2080
PY  - 2023
AB  - The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for the preclinical assessment of new treatment strategies for Alzheimer's disease. However, the properties of Aβ in such mice have not been systematically compared to Aβ in the brains of patients with Alzheimer's disease. Here, we determined the structures of nine ex vivo Aβ fibrils from six different mouse models by cryogenic-electron microscopy. We found novel Aβ fibril structures in the APP/PS1, ARTE10 and tg-SwDI models, whereas the human type II filament fold was found in the ARTE10, tg-APPSwe and APP23 models. The tg-APPArcSwe mice showed an Aβ fibril whose structure resembles the human type I filament found in patients with sporadic Alzheimer's disease. A detailed assessment of the Aβ fibril structure is key to the selection of adequate mouse models for the preclinical development of novel plaque-targeting therapeutics and positron emission tomography imaging tracers in Alzheimer's disease.
LB  - PUB:(DE-HGF)16
C6  - 37973869
UR  - <Go to ISI:>//WOS:001106141500001
DO  - DOI:10.1038/s41593-023-01484-4
UR  - https://juser.fz-juelich.de/record/1016976
ER  -