001017172 001__ 1017172
001017172 005__ 20231109201849.0
001017172 037__ $$aFZJ-2023-03985
001017172 1001_ $$0P:(DE-Juel1)130797$$aLettinga, M.P.$$b0$$eCorresponding author$$ufzj
001017172 1112_ $$a7th Int. Soft Matter Conference$$cOsaka$$d2023-09-04 - 2023-09-08$$wJapan
001017172 245__ $$aCompetition between deformation and free volumequantified by 3D image analysis of red blood cell
001017172 260__ $$c2023
001017172 3367_ $$033$$2EndNote$$aConference Paper
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001017172 520__ $$aCells in living organisms are subjected to mechanical strains caused by external forces like overcrowding, resulting in strong deformations that affect cell function. We study the interplay between deformation and crowding of red blood cells (RBCs) in dispersions of non-absorbing rod-like viruses. We identify a sequence of configurational transitions of RBC doublets, including configurations that can only be induced by long-ranged attraction: highly fluctuating T-shaped and face-to-face configurations at low, and doublets approaching a complete spherical configuration at high rod concentrations.Complementary simulations are used to explore different energy contributions to deformation as well as the stability of RBC doublet configurations. Our advanced analysis of 3D reconstructed confocal images of RBCs doublets quantifies the depletion interaction and the resulting deformation energy. Thus, we introduce a non-invasive method, high-throughput platform that is generally applicable to investigate the mechanical response of biological cells to external forces and characterize their mechanical properties.
001017172 536__ $$0G:(DE-HGF)POF4-5243$$a5243 - Information Processing in Distributed Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
001017172 7001_ $$0P:(DE-Juel1)176599$$aBabaki, Mehrnaz$$b1$$ufzj
001017172 7001_ $$0P:(DE-Juel1)177939$$aGholivand, Amirreza$$b2$$ufzj
001017172 7001_ $$0P:(DE-Juel1)188512$$aKorculanin, Olivera$$b3$$ufzj
001017172 7001_ $$0P:(DE-HGF)0$$aTuinier, Remco$$b4
001017172 7001_ $$0P:(DE-HGF)0$$aOpdam, Joeri$$b5
001017172 7001_ $$0P:(DE-HGF)0$$aWagner, Christian$$b6
001017172 7001_ $$0P:(DE-Juel1)140336$$aFedosov, Dmitry$$b7$$ufzj
001017172 909CO $$ooai:juser.fz-juelich.de:1017172$$pVDB
001017172 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)130797$$aForschungszentrum Jülich$$b0$$kFZJ
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001017172 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)188512$$aForschungszentrum Jülich$$b3$$kFZJ
001017172 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)140336$$aForschungszentrum Jülich$$b7$$kFZJ
001017172 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5243$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
001017172 9141_ $$y2023
001017172 920__ $$lyes
001017172 9201_ $$0I:(DE-Juel1)IBI-4-20200312$$kIBI-4$$lBiomakromolekulare Systeme und Prozesse$$x0
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001017172 980__ $$aI:(DE-Juel1)IBI-4-20200312
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