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@INPROCEEDINGS{Lettinga:1017172,
      author       = {Lettinga, M.P. and Babaki, Mehrnaz and Gholivand, Amirreza
                      and Korculanin, Olivera and Tuinier, Remco and Opdam, Joeri
                      and Wagner, Christian and Fedosov, Dmitry},
      title        = {{C}ompetition between deformation and free volumequantified
                      by 3{D} image analysis of red blood cell},
      reportid     = {FZJ-2023-03985},
      year         = {2023},
      abstract     = {Cells in living organisms are subjected to mechanical
                      strains caused by external forces like overcrowding,
                      resulting in strong deformations that affect cell function.
                      We study the interplay between deformation and crowding of
                      red blood cells (RBCs) in dispersions of non-absorbing
                      rod-like viruses. We identify a sequence of configurational
                      transitions of RBC doublets, including configurations that
                      can only be induced by long-ranged attraction: highly
                      fluctuating T-shaped and face-to-face configurations at low,
                      and doublets approaching a complete spherical configuration
                      at high rod concentrations.Complementary simulations are
                      used to explore different energy contributions to
                      deformation as well as the stability of RBC doublet
                      configurations. Our advanced analysis of 3D reconstructed
                      confocal images of RBCs doublets quantifies the depletion
                      interaction and the resulting deformation energy. Thus, we
                      introduce a non-invasive method, high-throughput platform
                      that is generally applicable to investigate the mechanical
                      response of biological cells to external forces and
                      characterize their mechanical properties.},
      month         = {Sep},
      date          = {2023-09-04},
      organization  = {7th Int. Soft Matter Conference, Osaka
                       (Japan), 4 Sep 2023 - 8 Sep 2023},
      subtyp        = {After Call},
      cin          = {IBI-4},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1017172},
}