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@INPROCEEDINGS{Lettinga:1017173,
      author       = {Lettinga, M.P. and Dedroog, Lens and Bartic, Carmen and
                      Deschaume, Olivier and Vananroy, Anja and Thielemans, Wim
                      and Coene, Yovan de},
      title        = {{I}nducing irreversible strain hardening and alignment
                      during collagen gelation},
      reportid     = {FZJ-2023-03986},
      year         = {2023},
      abstract     = {Collagen is one of the main building blocks of the
                      mammalian extracellular matrix, due to its ability to form
                      tough structures with a wide variety of non-linear
                      mechanical properties allowing it to support multiple tissue
                      types. The mechanical properties of collagen gels have been
                      extensively studied under static conditions, however, in
                      nature gelation will mostly take place in the presence of
                      flow. Here we show how the modulus and the alignment of the
                      fibrillar collagen hydrogel can be tuned by applying a
                      stress-ramp at a well-defined moment during gelation,
                      following up on our earlier study [1]. Where the first
                      stress block induces most of the final strain, sequential
                      increases in stress cause the modulus to rapidly increase
                      (see figure). This effect is more pronounced when gelation
                      takes place at 37 oC, where due to relatively rapid kinetics
                      a dense network of thin filaments is formed, than at 27 oC,
                      where slower kinetics result in the formation of an open
                      network with thick bundles. Contrary to the modulus, the
                      increase in alignment is more pronounced for the samples
                      formed at lower temperatures. Thus, we not only produce
                      tough gels with alignment, but also provide insight into in
                      vivo collagen structure formation.},
      month         = {Jul},
      date          = {2023-07-30},
      organization  = {International Conference on Rheology,
                       Athens (Greece), 30 Jul 2023 - 4 Aug
                       2023},
      subtyp        = {After Call},
      cin          = {IBI-4},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1017173},
}