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@ARTICLE{Koschinski:1017309,
      author       = {Koschinski, Lina and Lenyk, Bohdan and Jung, Marie and
                      Lenzi, Irene and Kampa, Björn and Mayer, Dirk and
                      Offenhäusser, Andreas and Musall, Simon and Rincón Montes,
                      Viviana},
      title        = {{V}alidation of transparent and flexible neural implants
                      for simultaneous electrophysiology, functional imaging, and
                      optogenetics},
      journal      = {Journal of materials chemistry / B},
      volume       = {11},
      number       = {40},
      issn         = {2050-750X},
      address      = {London ˜[u.a.]œ},
      publisher    = {RSC},
      reportid     = {FZJ-2023-04043},
      pages        = {9639 - 9657},
      year         = {2023},
      abstract     = {The combination of electrophysiology and neuroimaging
                      methods allows the simultaneous measurement of electrical
                      activity signals with calcium dynamics from single neurons
                      to neuronal networks across distinct brain regions in vivo.
                      While traditional electrophysiological techniques are
                      limited by photo-induced artefacts and optical occlusion for
                      neuroimaging, different types of transparent neural implants
                      have been proposed to resolve these issues. However,
                      reproducing proposed solutions is often challenging and it
                      remains unclear which approach offers the best properties
                      for long-term chronic multimodal recordings. We therefore
                      created a streamlined fabrication process to produce, and
                      directly compare, two types of transparent surface
                      micro-electrocorticography (μECoG) implants: nano-mesh gold
                      structures (m-μECoGs) versus a combination of solid gold
                      interconnects and PEDOT:PSS-based electrodes (pp-μECoGs).
                      Both implants allowed simultaneous multimodal recordings but
                      pp-μECoGs offered the best overall electrical,
                      electrochemical, and optical properties with negligible
                      photo-induced artefacts to light wavelengths of interest.
                      Showing functional chronic stability for up to four months,
                      pp-μECoGs also allowed the simultaneous functional mapping
                      of electrical and calcium neural signals upon visual and
                      tactile stimuli during widefield imaging. Moreover,
                      recordings during two-photon imaging showed no visible
                      signal attenuation and enabled the correlation of network
                      dynamics across brain regions to individual neurons located
                      directly below the transparent electrical contacts.},
      cin          = {IBI-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5254 - Neuroscientific Data Analytics and AI (POF4-525) /
                      5231 - Neuroscientific Foundations (POF4-523) / 5244 -
                      Information Processing in Neuronal Networks (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5254 / G:(DE-HGF)POF4-5231 /
                      G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1039/D3TB01191G},
      url          = {https://juser.fz-juelich.de/record/1017309},
}