TY  - JOUR
AU  - Kogler, Lydia
AU  - Müller, Veronika I.
AU  - Moser, Ewald
AU  - Windischberger, Christian
AU  - Gur, Ruben C.
AU  - Habel, Ute
AU  - Eickhoff, Simon B.
AU  - Derntl, Birgit
TI  - Testosterone and the Amygdala’s Functional Connectivity in Women and Men
JO  - Journal of Clinical Medicine
VL  - 12
IS  - 20
SN  - 2077-0383
CY  - Basel
PB  - MDPI
M1  - FZJ-2023-04153
SP  - 6501 -
PY  - 2023
N1  - This study was funded by the Deutsche Forschungsgemeinschaft (DFG; DE2319/2-4, DE2319/6-1, DE2319/9-1, HA 3202/18-1, IRTG 2804, EI 816/4-1 [SBE]; EI 816/6-1 [SBE]; LA 3071/3-1 [SBE]), the Medical Faculty, University of Tuebingen (fortune 2393-0-0 [LK]) the National Institute of Mental Health (R01-MH074457) (SBE) and R01-MH119219 (RCG), the European EFT program (Human Brain Project) (SBE) and the Austrian Science Foundation (Project FWF P-23533).
AB  - The amygdala contains androgen receptors and is involved in various affective and social functions. An interaction between testosterone and the amygdala’s functioning is likely. We investigated the amygdala’s resting-state functional connectivity (rsFC) network in association with testosterone in 94 healthy young adult women and men (final data available for analysis from 42 women and 39 men). Across the whole sample, testosterone was positively associated with the rsFC between the right amygdala and the right middle occipital gyrus, and it further predicted lower agreeableness scores. Significant sex differences appeared for testosterone and the functional connectivity between the right amygdala and the right superior frontal gyrus (SFG), showing higher testosterone levels with lower connectivity in women. Sex further predicted the openness and agreeableness scores. Our results show that testosterone modulates the rsFC between brain areas involved in affective processing and executive functions. The data indicate that the cognitive control of the amygdala via the frontal cortex is dependent on the testosterone levels in a sex-specific manner. Testosterone seems to express sex-specific patterns (1) in networks processing affect and cognition, and (2) in the frontal down-regulation of the amygdala. The sex-specific coupling between the amygdala and the frontal cortex in interaction with the hormone levels may drive sex-specific differences in a variety of behavioral phenomena that are further associated with psychiatric illnesses that show sex-specific prevalence rates.
LB  - PUB:(DE-HGF)16
C6  - 37892639
UR  - <Go to ISI:>//WOS:001093747600001
DO  - DOI:10.3390/jcm12206501
UR  - https://juser.fz-juelich.de/record/1017493
ER  -