% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kogler:1017493,
      author       = {Kogler, Lydia and Müller, Veronika I. and Moser, Ewald and
                      Windischberger, Christian and Gur, Ruben C. and Habel, Ute
                      and Eickhoff, Simon B. and Derntl, Birgit},
      title        = {{T}estosterone and the {A}mygdala’s {F}unctional
                      {C}onnectivity in {W}omen and {M}en},
      journal      = {Journal of Clinical Medicine},
      volume       = {12},
      number       = {20},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2023-04153},
      pages        = {6501 -},
      year         = {2023},
      note         = {This study was funded by the Deutsche
                      Forschungsgemeinschaft (DFG; DE2319/2-4, DE2319/6-1,
                      DE2319/9-1, HA 3202/18-1, IRTG 2804, EI 816/4-1 [SBE]; EI
                      816/6-1 [SBE]; LA 3071/3-1 [SBE]), the Medical Faculty,
                      University of Tuebingen (fortune 2393-0-0 [LK]) the National
                      Institute of Mental Health (R01-MH074457) (SBE) and
                      R01-MH119219 (RCG), the European EFT program (Human Brain
                      Project) (SBE) and the Austrian Science Foundation (Project
                      FWF P-23533).},
      abstract     = {The amygdala contains androgen receptors and is involved in
                      various affective and social functions. An interaction
                      between testosterone and the amygdala’s functioning is
                      likely. We investigated the amygdala’s resting-state
                      functional connectivity (rsFC) network in association with
                      testosterone in 94 healthy young adult women and men (final
                      data available for analysis from 42 women and 39 men).
                      Across the whole sample, testosterone was positively
                      associated with the rsFC between the right amygdala and the
                      right middle occipital gyrus, and it further predicted lower
                      agreeableness scores. Significant sex differences appeared
                      for testosterone and the functional connectivity between the
                      right amygdala and the right superior frontal gyrus (SFG),
                      showing higher testosterone levels with lower connectivity
                      in women. Sex further predicted the openness and
                      agreeableness scores. Our results show that testosterone
                      modulates the rsFC between brain areas involved in affective
                      processing and executive functions. The data indicate that
                      the cognitive control of the amygdala via the frontal cortex
                      is dependent on the testosterone levels in a sex-specific
                      manner. Testosterone seems to express sex-specific patterns
                      (1) in networks processing affect and cognition, and (2) in
                      the frontal down-regulation of the amygdala. The
                      sex-specific coupling between the amygdala and the frontal
                      cortex in interaction with the hormone levels may drive
                      sex-specific differences in a variety of behavioral
                      phenomena that are further associated with psychiatric
                      illnesses that show sex-specific prevalence rates.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37892639},
      UT           = {WOS:001093747600001},
      doi          = {10.3390/jcm12206501},
      url          = {https://juser.fz-juelich.de/record/1017493},
}