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@ARTICLE{Trner:1017567,
      author       = {Törner, Ricarda and Kupreichyk, Tatsiana and Hoyer,
                      Wolfgang and Boisbouvier, Jerome},
      title        = {{T}he role of heat shock proteins in preventing amyloid
                      toxicity},
      journal      = {Frontiers in molecular biosciences},
      volume       = {9},
      issn         = {2296-889X},
      address      = {Lausanne},
      publisher    = {Frontiers},
      reportid     = {FZJ-2023-04207},
      pages        = {1045616},
      year         = {2022},
      abstract     = {The oligomerization of monomeric proteins into large,
                      elongated, β-sheet-rich fibril structures (amyloid), which
                      results in toxicity to impacted cells, is highly correlated
                      to increased age. The concomitant decrease of the quality
                      control system, composed of chaperones, ubiquitin-proteasome
                      system and autophagy-lysosomal pathway, has been shown to
                      play an important role in disease development. In the last
                      years an increasing number of studies has been published
                      which focus on chaperones, modulators of protein
                      conformational states, and their effects on preventing
                      amyloid toxicity. Here, we give a comprehensive overview of
                      the current understanding of chaperones and amyloidogenic
                      proteins and summarize the advances made in elucidating the
                      impact of these two classes of proteins on each other,
                      whilst also highlighting challenges and remaining open
                      questions. The focus of this review is on structural and
                      mechanistic studies and its aim is to bring novices of this
                      field "up to speed" by providing insight into all the
                      relevant processes and presenting seminal structural and
                      functional investigations.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)36 / PUB:(DE-HGF)16},
      pubmed       = {36589244},
      UT           = {WOS:000905731200001},
      doi          = {10.3389/fmolb.2022.1045616},
      url          = {https://juser.fz-juelich.de/record/1017567},
}