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@ARTICLE{RiveraMorn:1017640,
      author       = {Rivera-Morán, J. Alejandro and Lang, Peter R.},
      title        = {{A}nalysing {S}ources of {E}rror in {T}otal {I}nternal
                      {R}eflection {M}icroscopy ({TIRM}) {E}xperiments and {D}ata
                      {A}nalysis},
      journal      = {Polymers},
      volume       = {15},
      number       = {21},
      issn         = {2073-4360},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2023-04256},
      pages        = {4208 -},
      year         = {2023},
      abstract     = {Many phenomena observed in synthetic and biological
                      colloidal suspensions are dominated by the static
                      interaction energies and the hydrodynamic interactions that
                      act both between individual particles and also between
                      colloids and macroscopic interfaces. This calls for methods
                      that allow precise measurements of the corresponding forces.
                      One method used for this purpose is total internal
                      reflection microscopy (TIRM), which has been employed for
                      around three decades to measure in particular the
                      interactions between a single particle suspended in a liquid
                      and a solid surface. However, given the importance of the
                      observable variables, it is crucial to understand the
                      possibilities and limitations of the method. In this paper,
                      we investigate the influence of technically unavoidable
                      noise effects and an inappropriate choice of particle size
                      and sampling time on TIRM measurement results. Our main
                      focus is on the measurement of diffusion coefficients and
                      drift velocities, as the influence of error sources on
                      dynamic properties has not been investigated so far. We find
                      that detector shot noise and prolonged sampling times may
                      cause erroneous results in the steep parts of the
                      interaction potential where forces of the order of
                      pico-Newtons or larger act on the particle, while the effect
                      of background noise is negligible below certain thresholds.
                      Furthermore, noise does not significantly affect dynamic
                      data but we find that lengthy sampling times and/or probe
                      particles with too small a radius will cause issues. Most
                      importantly, we observe that dynamic results are very likely
                      to differ from the standard hydrodynamic predictions for
                      stick boundary conditions due to partial slip.},
      cin          = {IBI-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37959890},
      UT           = {WOS:001100482200001},
      doi          = {10.3390/polym15214208},
      url          = {https://juser.fz-juelich.de/record/1017640},
}