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001017874 1001_ $$0P:(DE-HGF)0$$aBhalani, Deep$$b0
001017874 245__ $$aMolecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles Gelucire® 48/16 and Tetronics® 1304 in aqueous media
001017874 260__ $$aLondon$$bRSC Publishing$$c2023
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001017874 520__ $$aA comparative analysis of the micellar and solubilizing properties of two polyethylene glycol (PEG)-based amphiphilic biocompatible excipients: Gelucire® 48/16 (Ge 48/16) and Tetronics® 1304 (T1304), in the presence and absence of salt, was conducted. As there is a dearth of research in this area, the study aims to shed light on the behavior of these two nonionic surfactants and their potential as nanocarriers for solubilizing pharmaceuticals. Various techniques such as cloud point (CP), dynamic light scattering (DLS), small-angle neutron scattering (SANS), Fourier transform infrared spectroscopy (FT-IR), UV spectrophotometry, and high-performance liquid chromatography (HPLC) were employed. The solubility of quercetin (QCT), a flavonoid with anti-inflammatory, antioxidant, and anti-cancer properties, was evaluated and the interaction between QCT and the micellar system was examined. The analysis revealed the occurrence of strong interactions between QCT and surfactant molecules, resulting in enhanced solubility. It was observed that the micellar size and solubilizing ability were significantly improved in the presence of salt, while the CP decreased. Ge 48/16 exhibited superior performance, with a remarkable increase in the solubility of QCT in the presence of salt, suggesting its potential as an effective nanocarrier for a range of pharmaceutics, and yielding better therapeutic outcomes.
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001017874 7001_ $$0P:(DE-HGF)0$$aKakkad, Hiral$$b1
001017874 7001_ $$0P:(DE-HGF)0$$aModh, Jignasa$$b2
001017874 7001_ $$0P:(DE-Juel1)184311$$aRay, Debes$$b3
001017874 7001_ $$0P:(DE-HGF)0$$aAswal, Vinod K.$$b4
001017874 7001_ $$0P:(DE-HGF)0$$aPillai, Sadafara A.$$b5$$eCorresponding author
001017874 773__ $$0PERI:(DE-600)2623224-8$$a10.1039/D3RA04844F$$gVol. 13, no. 41, p. 28590 - 28601$$n41$$p28590 - 28601$$tRSC Advances$$v13$$x2046-2069$$y2023
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