TY  - JOUR
AU  - Bhalani, Deep
AU  - Kakkad, Hiral
AU  - Modh, Jignasa
AU  - Ray, Debes
AU  - Aswal, Vinod K.
AU  - Pillai, Sadafara A.
TI  - Molecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles Gelucire® 48/16 and Tetronics® 1304 in aqueous media
JO  - RSC Advances
VL  - 13
IS  - 41
SN  - 2046-2069
CY  - London
PB  - RSC Publishing
M1  - FZJ-2023-04387
SP  - 28590 - 28601
PY  - 2023
AB  - A comparative analysis of the micellar and solubilizing properties of two polyethylene glycol (PEG)-based amphiphilic biocompatible excipients: Gelucire® 48/16 (Ge 48/16) and Tetronics® 1304 (T1304), in the presence and absence of salt, was conducted. As there is a dearth of research in this area, the study aims to shed light on the behavior of these two nonionic surfactants and their potential as nanocarriers for solubilizing pharmaceuticals. Various techniques such as cloud point (CP), dynamic light scattering (DLS), small-angle neutron scattering (SANS), Fourier transform infrared spectroscopy (FT-IR), UV spectrophotometry, and high-performance liquid chromatography (HPLC) were employed. The solubility of quercetin (QCT), a flavonoid with anti-inflammatory, antioxidant, and anti-cancer properties, was evaluated and the interaction between QCT and the micellar system was examined. The analysis revealed the occurrence of strong interactions between QCT and surfactant molecules, resulting in enhanced solubility. It was observed that the micellar size and solubilizing ability were significantly improved in the presence of salt, while the CP decreased. Ge 48/16 exhibited superior performance, with a remarkable increase in the solubility of QCT in the presence of salt, suggesting its potential as an effective nanocarrier for a range of pharmaceutics, and yielding better therapeutic outcomes.
LB  - PUB:(DE-HGF)16
C6  - 37780735
UR  - <Go to ISI:>//WOS:001072912300001
DO  - DOI:10.1039/D3RA04844F
UR  - https://juser.fz-juelich.de/record/1017874
ER  -