% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Bhalani:1017874,
      author       = {Bhalani, Deep and Kakkad, Hiral and Modh, Jignasa and Ray,
                      Debes and Aswal, Vinod K. and Pillai, Sadafara A.},
      title        = {{M}olecular insights into the aggregation and solubilizing
                      behavior of biocompatible amphiphiles {G}elucire® 48/16 and
                      {T}etronics® 1304 in aqueous media},
      journal      = {RSC Advances},
      volume       = {13},
      number       = {41},
      issn         = {2046-2069},
      address      = {London},
      publisher    = {RSC Publishing},
      reportid     = {FZJ-2023-04387},
      pages        = {28590 - 28601},
      year         = {2023},
      abstract     = {A comparative analysis of the micellar and solubilizing
                      properties of two polyethylene glycol (PEG)-based
                      amphiphilic biocompatible excipients: Gelucire® 48/16 (Ge
                      48/16) and Tetronics® 1304 (T1304), in the presence and
                      absence of salt, was conducted. As there is a dearth of
                      research in this area, the study aims to shed light on the
                      behavior of these two nonionic surfactants and their
                      potential as nanocarriers for solubilizing pharmaceuticals.
                      Various techniques such as cloud point (CP), dynamic light
                      scattering (DLS), small-angle neutron scattering (SANS),
                      Fourier transform infrared spectroscopy (FT-IR), UV
                      spectrophotometry, and high-performance liquid
                      chromatography (HPLC) were employed. The solubility of
                      quercetin (QCT), a flavonoid with anti-inflammatory,
                      antioxidant, and anti-cancer properties, was evaluated and
                      the interaction between QCT and the micellar system was
                      examined. The analysis revealed the occurrence of strong
                      interactions between QCT and surfactant molecules, resulting
                      in enhanced solubility. It was observed that the micellar
                      size and solubilizing ability were significantly improved in
                      the presence of salt, while the CP decreased. Ge 48/16
                      exhibited superior performance, with a remarkable increase
                      in the solubility of QCT in the presence of salt, suggesting
                      its potential as an effective nanocarrier for a range of
                      pharmaceutics, and yielding better therapeutic outcomes.},
      cin          = {IBI-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37780735},
      UT           = {WOS:001072912300001},
      doi          = {10.1039/D3RA04844F},
      url          = {https://juser.fz-juelich.de/record/1017874},
}