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@INPROCEEDINGS{PalomeroGallagher:1018409,
      author       = {Palomero-Gallagher, Nicola},
      title        = {{H}igh resolution cyto-, myelo- and receptor architectonic
                      atlas of the macaque monkey brain},
      reportid     = {FZJ-2023-04790},
      year         = {2023},
      abstract     = {One of the biggest challenges in understanding the brain is
                      being able to discern how the molecular, cellular and
                      systemic levels of organization relate to each other to
                      enable cognitive functions and the control of behavior. The
                      combined analysis of the cytoarchitectonic segregation of
                      the cerebral cortex and of the regional and laminar
                      distribution patterns of multiple neurotransmitter
                      receptors, which constitute key molecules of signal
                      processing in the brain, has revealed that their densities
                      vary considerably between different cytoarchitectonically
                      defined areas, thus revealing their borders and enabling
                      their multimodal characterization. Furthermore, the specific
                      balance in the expression levels of different receptors
                      within a cytoarchitectonically defined area, i.e., the
                      receptor fingerprint of that area, varies systematically
                      depending on the participation of cortical areas in
                      different functional networks, thus indicating the
                      hierarchical aspects of systemic functional organization.I
                      here present a novel atlas of the macaque monkey brain
                      encompassing an ultra high-resolution 3D histological volume
                      as well as 3D cortical maps encoding the regional and
                      laminar distribution patterns of 14 different
                      neurotransmitter receptors and associated with the
                      stereotaxic space created by the MEBRAINS template and the
                      volumetric representation of the Yerkes 19 template. This
                      resource which will enable for the first time a voxel-wise
                      whole brain analysis of the regional and laminar
                      distribution patterns of multiple receptor types in one and
                      the same macaque monkey brain. This multimodal and
                      multiscale atlas spanning multiple orders of magnitude is
                      accompanied by a parcellation scheme of the frontal,
                      parietal and occipital cortices based on a quantitative
                      analysis of their cyto- and receptor architecture, as well
                      as of the hippocampus and subcortical structures such as
                      amygdalar nuclei, the striatum and the globus pallidus. This
                      atlas will enable a comprehensive analysis of the molecular,
                      cellular and systemic organization of the macaque monkey
                      brain, which must be understood as being topographically
                      specific and structurally/functionally segregated in order
                      to recognize the organizational principles that make it an
                      interconnected system of complex structural and functional
                      units. This resource will enable systematic analyses of the
                      hierarchical relationships between these units, thus
                      providing crucial insights into the structural segregation
                      underlying the brain’s functional organization.},
      month         = {Oct},
      date          = {2023-10-04},
      organization  = {7th BigBrain Workshop, Reykjavík
                       (Iceland), 4 Oct 2023 - 6 Oct 2023},
      subtyp        = {After Call},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HIBALL - Helmholtz International BigBrain
                      Analytics and Learning Laboratory (HIBALL) (InterLabs-0015)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)InterLabs-0015},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1018409},
}