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| Hauptseite > Publikationsdatenbank > Clinical subtypes in patients with isolated REM sleep behaviour disorder > print |
| Hauptseite > Publikationsdatenbank > Clinical subtypes in patients with isolated REM sleep behaviour disorder > print |
| 001 | 1018436 | ||
| 005 | 20231213115708.0 | ||
| 024 | 7 | _ | |a 10.1038/s41531-023-00598-7 |2 doi |
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| 100 | 1 | _ | |a Seger, Aline |0 P:(DE-Juel1)184882 |b 0 |u fzj |
| 245 | _ | _ | |a Clinical subtypes in patients with isolated REM sleep behaviour disorder |
| 260 | _ | _ | |a London [u.a.] |c 2023 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Patients with Parkinson's disease (PD) show a broad heterogeneity in dinical presentation, and subtypes may already arise inprodromal disease stages. lsolated REM sleep behaviour disorder (iRBD) is the most specific marker of prodromal PD, but data ondinical subtyping of patients with iRBD remain scarce. Therefore, this study aimed to identify iRBD subtypes. We conductedcomprehensive dinical assessments in 66 patients with polysomnography-proven iRBD, induding motor and non-motorevaluations, and applied a two-step duster analysis. Besides, we compared iRBD dusters to matched healthy controls and relatedthe resulting duster solution to cortical and subcortical grey matter volumes by voxel-based morphometry analysis. We identifiedtwo distinct subtypes of patients based on olfactory function, dominant electroencephalography frequency, amount of REM sleepwithout atonia, depressive symptoms, disease duration, and motor functions. One iRBD duster (Cluster 1, late onset-aggressive)was characterised by higher non-motor symptom burden despite shorter disease duration than the more benign subtype (Cluster II,early onset-benign). Motor functions were comparable between the dusters. Patients from Cluster I were significantly older atiRBD onset and exhibited a widespread reduction of cortical grey matter volume compared to patients from Cluster II. In condusion,our findings suggest the existence of dinical subtypes already in the prodromal stage of PD. Future longitudinal studies arewarranted that replicate these findings and investigate the risk of the more aggressive phenotype for earlier phenoconversion anddementia development. |
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| 536 | _ | _ | |a DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) |0 G:(GEPRIS)431549029 |c 431549029 |x 1 |
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| 700 | 1 | _ | |a Ophey, Anja |0 0000-0001-5858-7762 |b 1 |
| 700 | 1 | _ | |a Doppler, Christopher E. J. |0 P:(DE-Juel1)161350 |b 2 |
| 700 | 1 | _ | |a Kickartz, Johanna |b 3 |
| 700 | 1 | _ | |a Lindner, Marie-Sophie |b 4 |
| 700 | 1 | _ | |a Hommelsen, Maximilian |0 P:(DE-Juel1)173028 |b 5 |
| 700 | 1 | _ | |a Fink, Gereon R. |0 P:(DE-Juel1)131720 |b 6 |u fzj |
| 700 | 1 | _ | |a Sommerauer, Michael |0 P:(DE-Juel1)179044 |b 7 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.1038/s41531-023-00598-7 |g Vol. 9, no. 1, p. 155 |0 PERI:(DE-600)2819218-7 |n 1 |p 155 |t npj Parkinson's Disease |v 9 |y 2023 |x 2373-8057 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1018436/files/PDF.pdf |y OpenAccess |
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