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001018488 005__ 20250811101250.0
001018488 0247_ $$2doi$$a10.25493/6H8D-4TC
001018488 037__ $$aFZJ-2023-04847
001018488 1001_ $$0P:(DE-Juel1)158043$$aZachlod, Daniel$$b0
001018488 245__ $$aCombined analysis of cytoarchitectonic, molecular and transcriptomic patterns reveal differences in brain organization across human functional brain systems (v1.0)
001018488 260__ $$bEBRAINS$$c2023
001018488 3367_ $$2BibTeX$$aMISC
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001018488 520__ $$aBrain areas show specific cellular, molecular, and gene expression patterns that are linked to function, but their precise relationships are largely unknown. To unravel these structure-function relationships, a combined analysis of 53 neurotransmitter receptor genes, receptor densities of six transmitter systems and cytoarchitectonic data of the auditory, somatosensory, visual, motor systems was conducted. Besides covariation of areal gene expression with receptor density, the study reveals specific gene expression patterns in functional systems, which are most prominent for the inhibitory GABAA and excitatory glutamatergic NMDA receptors. Furthermore, gene expression-receptor relationships changed in a systematic manner according to information flow from primary to higher associative areas. The findings shed new light on the relationship of anatomical, functional, and molecular and transcriptomic principles of cortical segregation towards a more comprehensive understanding of human brain organization.
001018488 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001018488 588__ $$aDataset connected to DataCite
001018488 650_7 $$2Other$$aNeuroscience
001018488 7001_ $$0P:(DE-Juel1)131636$$aBludau, Sebastian$$b1
001018488 7001_ $$0P:(DE-Juel1)140234$$aCichon, Sven$$b2
001018488 7001_ $$0P:(DE-Juel1)131701$$aPalomero-Gallagher, Nicola$$b3
001018488 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b4
001018488 7001_ $$0P:(DE-Juel1)158043$$aZachlod, Daniel$$b5
001018488 773__ $$a10.25493/6H8D-4TC
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001018488 9141_ $$y2023
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