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@MISC{Zachlod:1018488,
      author       = {Zachlod, Daniel and Bludau, Sebastian and Cichon, Sven and
                      Palomero-Gallagher, Nicola and Amunts, Katrin and Zachlod,
                      Daniel},
      title        = {{C}ombined analysis of cytoarchitectonic, molecular and
                      transcriptomic patterns reveal differences in brain
                      organization across human functional brain systems (v1.0)},
      publisher    = {EBRAINS},
      reportid     = {FZJ-2023-04847},
      year         = {2023},
      abstract     = {Brain areas show specific cellular, molecular, and gene
                      expression patterns that are linked to function, but their
                      precise relationships are largely unknown. To unravel these
                      structure-function relationships, a combined analysis of 53
                      neurotransmitter receptor genes, receptor densities of six
                      transmitter systems and cytoarchitectonic data of the
                      auditory, somatosensory, visual, motor systems was
                      conducted. Besides covariation of areal gene expression with
                      receptor density, the study reveals specific gene expression
                      patterns in functional systems, which are most prominent for
                      the inhibitory GABAA and excitatory glutamatergic NMDA
                      receptors. Furthermore, gene expression-receptor
                      relationships changed in a systematic manner according to
                      information flow from primary to higher associative areas.
                      The findings shed new light on the relationship of
                      anatomical, functional, and molecular and transcriptomic
                      principles of cortical segregation towards a more
                      comprehensive understanding of human brain organization.},
      keywords     = {Neuroscience (Other)},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)32},
      doi          = {10.25493/6H8D-4TC},
      url          = {https://juser.fz-juelich.de/record/1018488},
}