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@ARTICLE{Cepkenovic:1018534,
      author       = {Cepkenovic, Bogdana and Friedland, Florian and
                      Noetzel-Reiss, Erik and Maybeck, Vanessa and Offenhäusser,
                      Andreas},
      title        = {{S}ingle-neuron mechanical perturbation evokes calcium
                      plateaus that excite and modulate the network},
      journal      = {Scientific reports},
      volume       = {13},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2023-04862},
      pages        = {20669},
      year         = {2023},
      abstract     = {Mechanical stimulation is a promising means to
                      non-invasively excite and modulate neuronal networks with a
                      high spatial resolution. Despite the thorough
                      characterization of the initiation mechanism, whether or how
                      mechanical responses disperse into non-target areas remains
                      to be discovered. Our in vitro study demonstrates that a
                      single-neuron deformation evokes responses that propagate to
                      about a third of the untouched neighbors. The responses
                      develop via calcium influx through mechanosensitive channels
                      and regeneratively propagate through the neuronal ensemble
                      via gap junctions. Although independent of action potentials
                      and synapses, mechanical responses reliably evoke membrane
                      depolarizations capable of inducing action potentials both
                      in the target and neighbors. Finally, we show that
                      mechanical stimulation transiently potentiates the
                      responding assembly for further inputs, as both gain and
                      excitability are transiently increased exclusively in
                      neurons that respond to a neighbor’s mechanical
                      stimulation. The findings indicate a biological component
                      affecting the spatial resolution of mechanostimulation and
                      point to a cross-talk in broad-network mechanical
                      stimulations. Since giga-seal formation in patch-clamp
                      produces a similar mechanical stimulus on the neuron, our
                      findings inform which neuroscientific questions could be
                      reliably tackled with patch-clamp and what recovery
                      post-gigaseal formation is necessary.},
      cin          = {IBI-3 / IBI-2},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-3-20200312 / I:(DE-Juel1)IBI-2-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38001109},
      UT           = {WOS:001136085000061},
      doi          = {10.1038/s41598-023-47090-z},
      url          = {https://juser.fz-juelich.de/record/1018534},
}