TY  - JOUR
AU  - van der Linden, Christina
AU  - Berger, Thea
AU  - Brandt, Gregor A.
AU  - Strelow, Joshua N.
AU  - Jergas, Hannah
AU  - Baldermann, Juan Carlos
AU  - Visser-Vandewalle, Veerle
AU  - Fink, Gereon Rudolf
AU  - Barbe, Michael T.
AU  - Petry-Schmelzer, Jan Niklas
AU  - Dembek, Till A.
TI  - Accelerometric Classification of Resting and Postural Tremor Amplitude
JO  - Sensors
VL  - 23
IS  - 20
SN  - 1424-8220
CY  - Basel
PB  - MDPI
M1  - FZJ-2023-04867
SP  - 8621 -
PY  - 2023
AB  - Clinical rating scales for tremors have significant limitations due to low resolution, high rater dependency, and lack of applicability in outpatient settings. Reliable, quantitative approaches for assessing tremor severity are warranted, especially evaluating treatment effects, e.g., of deep brain stimulation (DBS). We aimed to investigate how different accelerometry metrics can objectively classify tremor amplitude of Essential Tremor (ET) and tremor in Parkinson's Disease (PD). We assessed 860 resting and postural tremor trials in 16 patients with ET and 25 patients with PD under different DBS settings. Clinical ratings were compared to different metrics, based on either spectral components in the tremorband or pure acceleration, derived from simultaneous triaxial accelerometry captured at the index finger and wrist. Nonlinear regression was applied to a training dataset to determine the relationship between accelerometry and clinical ratings, which was then evaluated in a holdout dataset. All of the investigated accelerometry metrics could predict clinical tremor ratings with a high concordance (>70%) and substantial interrater reliability (Cohen's weighted Kappa > 0.7) in out-of-sample data. Finger-worn accelerometry performed slightly better than wrist-worn accelerometry. We conclude that triaxial accelerometry reliably quantifies resting and postural tremor amplitude in ET and PD patients. A full release of our dataset and software allows for implementation, development, training, and validation of novel methods.Keywords: Parkinson’s Disease; accelerometry; essential tremor; tremor; wearables.
LB  - PUB:(DE-HGF)16
C6  - 37896714
UR  - <Go to ISI:>//WOS:001099382400001
DO  - DOI:10.3390/s23208621
UR  - https://juser.fz-juelich.de/record/1018539
ER  -