TY  - JOUR
AU  - Filss, Christian
AU  - Cramer, Julian
AU  - Löher, Saskia
AU  - Lohmann, Philipp
AU  - Stoffels, Gabriele
AU  - Stegmayr, Carina
AU  - Kocher, Martin
AU  - Heinzel, Alexander
AU  - Galldiks, Norbert
AU  - Wittsack, Hans J.
AU  - Sabel, Michael
AU  - Neumaier, Bernd
AU  - Scheins, Jürgen
AU  - Shah, N. Jon
AU  - Meyer, Philipp T.
AU  - Mottaghy, Felix M.
AU  - Langen, Karl-Josef
TI  - Assessment of Brain Tumour Perfusion Using Early-Phase 18F-FET PET: Comparison with Perfusion-Weighted MRI
JO  - Molecular imaging & biology
VL  - 26
SN  - 1536-1632
CY  - Cham
PB  - Springer Nature Switzerland
M1  - FZJ-2023-04869
SP  - 36-44
PY  - 2024
AB  - AbstractPurpose Morphological imaging using MRI is essential for brain tumour diagnostics. Dynamic susceptibility contrast (DSC)perfusion-weighted MRI (PWI), as well as amino acid PET, may provide additional information in ambiguous cases. SincePWI is often unavailable in patients referred for amino acid PET, we explored whether maps of relative cerebral blood volume(rCBV) in brain tumours can be extracted from the early phase of PET using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET).Procedure Using a hybrid brain PET/MRI scanner, PWI and dynamic 18F-FET PET were performed in 33 patients withcerebral glioma and four patients with highly vascularized meningioma. The time interval from 0 to 2 min p.i. was selectedto best reflect the blood pool phase in 18F-FET PET. For each patient, maps of MR-rCBV, early 18F-FET PET (0–2 min p.i.)and late 18F-FET PET (20–40 min p.i.) were generated and coregistered. Volumes of interest were placed on the tumour(VOI-TU) and normal-appearing brain (VOI-REF). The correlation between tumour-to-brain ratios (TBR) of the differentparameters was analysed. In addition, three independent observers evaluated MR-rCBV and early 18F-FET maps (18F-FETrCBV)for concordance in signal intensity, tumour extent and intratumoural distribution.Results TBRs calculated from MR-rCBV and 18F-FET-rCBV showed a significant correlation (r = 0.89, p < 0.001), whilethere was no correlation between late 18F-FET PET and MR-rCBV (r = 0.24, p = 0.16) and 18F-FET-rCBV (r = 0.27, p =0.11). Visual rating yielded widely agreeing findings or only minor differences between MR-rCBV maps and 18F-FET-rCBVmaps in 93 % of the tumours (range of three independent raters 91–94%, kappa among raters 0.78–1.0).Conclusion Early 18F-FET maps (0–2 min p.i.) in gliomas provide similar information to MR-rCBV maps and may be helpfulwhen PWI is not possible or available. Further studies in gliomas are needed to evaluate whether 18F-FET-rCBV providesthe same clinical information as MR-rCBV.Keywords Brain tumour · Glioma · PWI · rCBV · Early FET PET · Glioma · O-(2-18F-Fluoroethyl)-L-tyrosine · Aminoacid PET
LB  - PUB:(DE-HGF)16
C6  - 37848641
UR  - <Go to ISI:>//WOS:001183226500001
DO  - DOI:10.1007/s11307-023-01861-2
UR  - https://juser.fz-juelich.de/record/1018541
ER  -