% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Filss:1018541,
      author       = {Filss, Christian and Cramer, Julian and Löher, Saskia and
                      Lohmann, Philipp and Stoffels, Gabriele and Stegmayr, Carina
                      and Kocher, Martin and Heinzel, Alexander and Galldiks,
                      Norbert and Wittsack, Hans J. and Sabel, Michael and
                      Neumaier, Bernd and Scheins, Jürgen and Shah, N. Jon and
                      Meyer, Philipp T. and Mottaghy, Felix M. and Langen,
                      Karl-Josef},
      title        = {{A}ssessment of {B}rain {T}umour {P}erfusion {U}sing
                      {E}arly-{P}hase 18{F}-{FET} {PET}: {C}omparison with
                      {P}erfusion-{W}eighted {MRI}},
      journal      = {Molecular imaging $\&$ biology},
      volume       = {26},
      issn         = {1536-1632},
      address      = {Cham},
      publisher    = {Springer Nature Switzerland},
      reportid     = {FZJ-2023-04869},
      pages        = {36-44},
      year         = {2024},
      abstract     = {AbstractPurpose Morphological imaging using MRI is
                      essential for brain tumour diagnostics. Dynamic
                      susceptibility contrast (DSC)perfusion-weighted MRI (PWI),
                      as well as amino acid PET, may provide additional
                      information in ambiguous cases. SincePWI is often
                      unavailable in patients referred for amino acid PET, we
                      explored whether maps of relative cerebral blood
                      volume(rCBV) in brain tumours can be extracted from the
                      early phase of PET using O-(2-18F-fluoroethyl)-L-tyrosine
                      (18F-FET).Procedure Using a hybrid brain PET/MRI scanner,
                      PWI and dynamic 18F-FET PET were performed in 33 patients
                      withcerebral glioma and four patients with highly
                      vascularized meningioma. The time interval from 0 to 2 min
                      p.i. was selectedto best reflect the blood pool phase in
                      18F-FET PET. For each patient, maps of MR-rCBV, early
                      18F-FET PET (0–2 min p.i.)and late 18F-FET PET (20–40
                      min p.i.) were generated and coregistered. Volumes of
                      interest were placed on the tumour(VOI-TU) and
                      normal-appearing brain (VOI-REF). The correlation between
                      tumour-to-brain ratios (TBR) of the differentparameters was
                      analysed. In addition, three independent observers evaluated
                      MR-rCBV and early 18F-FET maps (18F-FETrCBV)for concordance
                      in signal intensity, tumour extent and intratumoural
                      distribution.Results TBRs calculated from MR-rCBV and
                      18F-FET-rCBV showed a significant correlation (r = 0.89, p <
                      0.001), whilethere was no correlation between late 18F-FET
                      PET and MR-rCBV (r = 0.24, p = 0.16) and 18F-FET-rCBV (r =
                      0.27, p =0.11). Visual rating yielded widely agreeing
                      findings or only minor differences between MR-rCBV maps and
                      18F-FET-rCBVmaps in 93 $\%$ of the tumours (range of three
                      independent raters $91–94\%,$ kappa among raters
                      0.78–1.0).Conclusion Early 18F-FET maps (0–2 min p.i.)
                      in gliomas provide similar information to MR-rCBV maps and
                      may be helpfulwhen PWI is not possible or available. Further
                      studies in gliomas are needed to evaluate whether
                      18F-FET-rCBV providesthe same clinical information as
                      MR-rCBV.Keywords Brain tumour · Glioma · PWI · rCBV ·
                      Early FET PET · Glioma · O-(2-18F-Fluoroethyl)-L-tyrosine
                      · Aminoacid PET},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37848641},
      UT           = {WOS:001183226500001},
      doi          = {10.1007/s11307-023-01861-2},
      url          = {https://juser.fz-juelich.de/record/1018541},
}