TY  - JOUR
AU  - Song, Li
AU  - Wang, Pengfei
AU  - Li, Hui
AU  - Weiss-Blankenhorn, Peter
AU  - Fink, Gereon R
AU  - Zhou, Xiaolin
AU  - Chen, Qi
TI  - Increased functional connectivity between the auditory cortex and the frontoparietal network compensates for impaired visuomotor transformation after early auditory deprivation
JO  - Cerebral cortex
VL  - 33
IS  - 22
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2023-04871
SP  - 11126 - 11145
PY  - 2023
AB  - AbstractEarly auditory deprivation leads to a reorganization of large-scale brain networks involving and extending beyond the auditory system. It has been documented that visuomotor transformation is impaired after early deafness, associated with a hyper-crosstalk between the task-critical frontoparietal network and the default-mode network. However, it remains unknown whether and how the reorganized large-scale brain networks involving the auditory cortex contribute to impaired visuomotor transformation after early deafness. Here, we asked deaf and early hard of hearing participants and normal hearing controls to judge the spatial location of a visual target. Compared with normal hearing controls, the superior temporal gyrus showed significantly increased functional connectivity with the frontoparietal network and the default-mode network in deaf and early hard of hearing participants, specifically during egocentric judgments. However, increased superior temporal gyrus-frontoparietal network and superior temporal gyrus-default-mode network coupling showed antagonistic effects on egocentric judgments. In deaf and early hard of hearing participants, increased superior temporal gyrus-frontoparietal network connectivity was associated with improved egocentric judgments, whereas increased superior temporal gyrus-default-mode network connectivity was associated with deteriorated performance in the egocentric task. Therefore, the data suggest that the auditory cortex exhibits compensatory neuroplasticity (i.e. increased functional connectivity with the task-critical frontoparietal network) to mitigate impaired visuomotor transformation after early auditory deprivation.Keywords: connectomics; deaf and early hard of hearing; modularity; neural plasticity; superior temporal gyrus.
LB  - PUB:(DE-HGF)16
C6  - 37814363
UR  - <Go to ISI:>//WOS:001078075700001
DO  - DOI:10.1093/cercor/bhad351
UR  - https://juser.fz-juelich.de/record/1018543
ER  -